Dr. Lee, Eminy H.Y.
Distinguished Research Fellow
- 02-27899125 (Lab) (Room No: 308)
- 02-27829224 (Fax)
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Specialty:
- Pathogenesis of and Neuroprotection against Alzheimer's Disease
- Molecular Mechanism of Mammalian Long-Term Memory Formation
Education and Positions:
Ph.D. Univ. of California, San Diego
Highlight Detail
Laminin-β1 Impairs Spatial Learning through Inhibition of ERK/MAPK and SGK1 Signaling.
Dr. Lee, Eminy H.Y.
Neuropsychopharmacology, Aug 17, 2011Laminin is a major structural element of the basal lamina consisting of an α-chain, a β-chain, and a γ-chain arranged in a cross-like structure, with their C-terminal inter-coiled. Laminin is abundantly expressed in the hippocampus of mature brain and is implicated in several psychiatric disorders, but its possible role involved in learning and memory function is not known. This issue was examined here. Our results revealed that water maze training significantly decreased laminin-β1 (LB1) expression in the rat hippocampal CA1 area.