Dr. Lee, Eminy H.Y. 李小媛 博士

List of Highlights
文件紀錄

• Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation

  Molecular Therapy Sep 05, 2020

• Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome

  Scientific Reports Jan 23, 2020

• Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer’s disease

  Cell Death & Differentiation May 24, 2019

• PIAS1 Ser‐503 phosphorylation‐mediated Elk‐1 SUMOylation promotes neuronal survival in APP/PS1 mice

  British Journal of Pharmacology Mar 08, 2019

• Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2

  BMC Biology Nov 28, 2017

• Galectin-3 Negatively Regulates Hippocampus-Dependent Memory Formation through Inhibition of Integrin Signaling and Galectin-3 Phosphorylation

  Frontiers in Molecular Neuroscience Jul 11, 2017

• Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer’s disease

  Cell Death and Differentiation Feb 10, 2017

• MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome.

  Nature Communications Feb 04, 2016

• SUMO modification of Akt regulates global SUMOylation and substrate SUMOylation specificity through Akt phosphorylation of Ubc9 and SUMO1

  Oncogene Feb 04, 2016

• CREB SUMOylation by the E3 Ligase PIAS1 Enhances Spatial Memory.

  J. Neurosci. Jul 16, 2014

• STAT1 Negatively Regulates Spatial Memory Formation and Mediates the Memory-Impairing Effect of Aβ.

  Neuropsychopharmacology Feb 15, 2014

• NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.

  Neuropharmacology Feb 01, 2013

• JNK1 Inhibits GluR1 Expression and GluR1-Mediated Calcium Influx through Phosphorylation and Stabilization of Hes-1.

  J Neurosci. Feb 01, 2012

• Laminin-β1 Impairs Spatial Learning through Inhibition of ERK/MAPK and SGK1 Signaling.

  Neuropsychopharmacology Aug 17, 2011

• Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning.

  EMBO J Nov 19, 2010

• A novel defense mechanism that is activated on amyloid-beta insult to mediate cell survival: role of SGK1-STAT1/STAT2 signaling.

  Cell Death Differ. Jul 17, 2009

• Protein Kinase CK2 Impairs Spatial Memory Formation through Differential Cross Talk with PI-3 Kinase Signaling: Activation of Akt and Inactivation of SGK1.

  The Journal of Neuroscience Jun 06, 2007

• Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) Increases Neurite Formation through Microtubule Depolymerization by SGK1 and by SGK1 Phosphorylation of Tau.

  Mol. Cell. Biol. Sep 18, 2006