HIGHLIGHT
重要成果
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- Lymph Node Follicle-Targeting STING Agonist Nanoshells Enable Single-Shot M2e Vaccination for Broad and Durable Influenza Protection
- Advanced Science, Apr 24, 2023
- The highly conserved matrix protein 2 ectodomain (M2e) of influenza viruses presents a compelling vaccine anti ......
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- Engineering Cyborg Bacteria Through Intracellular Hydrogelation
- Advanced Science, Jan 11, 2023
- Natural and artificial cells are two common chassis in synthetic biology. Natural cells can perform complex ta ......
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- In Situ Hydrogelation of Cellular Monolayers Enables Conformal Biomembrane Functionalization for Xeno-Free Feeder Substrate Engineering
- Advanced Healthcare Materials, Dec 01, 2022
- The intricate biochemical functionalities of cellular membranes have inspired numerous strategies for deriving ......
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- Integrated Design of a Membrane-Lytic Peptide-Based Intravenous Nanotherapeutic Suppresses Triple-Negative Breast Cancer
- Advanced Science, Mar 04, 2022
- Membrane-lytic peptides offer broad synthetic flexibilities and design potential to the arsenal of anticancer ......
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- Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation
- Advanced Materials, Jun 07, 2021
- The growing enthusiasm for cancer immunotherapies and adoptive cell therapies has prompted increasing interest in biom ......
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- Robust induction of TRMs by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses
- Methods & Clinical Development, Mar 23, 2021
- Antigen-specific lung-resident memory T cells (TRMs) constitute the first line of defense that mediates rapid prote ......
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- Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control
- Drug Delivery and Translational Research, Mar 21, 2021
- The COVID-19 pandemic's high mortality rate and severe socioeconomic impact serve as a reminder of the urgent need f ......
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- Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy
- Nano Letters, Mar 17, 2020
- Many favorable anticancer treatments owe their success to the induction immunogenic cell death (ICD) in cancer cells, which results in the r ......
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- Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus
- Advanced Functional Materials, Apr 12, 2019
- The continued threat of emerging, highly lethal infectious pathogens such as Middle East respiratory syndrome coronavirus (MERS‐CoV) calls f ......
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- Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions
- Nature Communications, Mar 05, 2019
- Cell membranes are an intricate yet fragile interface that requires substrate support for stabilization. Upon cell death, disassembly of the ......
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