Dr. Lin, Jung-Hsin
Joint Appointment Research Fellow
- 26523993 (IBMS) (Lab) (Room No: 234)
- (02) 2787-3143 (RCAS)
- (02) 2787-3122 (Fax)
-
Specialty:
- Pharmacoinformatics
- Computational Biophysics
Education and Positions:
Ph.D., University of Duisburg, Germany
Highlight Detail
Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation.
Dr. Lin, Jung-Hsin
Nucleic Acids Res., Jul 06, 2015Type II topoisomerases resolve topological problems of DNA double helices by passing one duplex through the reversible double-stranded break they generated on another duplex. Despite the wealth of information in the cleaving operation, molecular understanding of the enzymatic DNA ligation remains elusive. Topoisomerase poisons are widely used in anti-cancer and anti-bacterial therapy and have been employed to entrap the intermediates of topoisomerase IIβ with religatable DNA substrate.