Dr. Chen, Joanne Jeou-Yuan 張久瑗 博士



CD44 Engagement Promotes Matrix-derived Survival through CD44-SRC-integrin Axis in Lipid Rafts.

Mol. Cell. Biol. Jul 21, 2008

CD44 is present in detergent-resistant cholesterol-rich microdomains, called lipid rafts, in many types of cells. However, the functional significance of CD44 in lipid rafts is still unknown. We have previously demonstrated that osteopontin-mediated engagement of CD44V promotes an extracellular matrix-derived survival signal through integrin activation. By using a series of CD44 mutants and pharmacological inhibitors selectively targeted to various cellular pathways

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