Dr. Chen, Joanne Jeou-Yuan
Emeritus Research Fellow
Specialty:
- Cancer Genomics
- Molecular Oncology
- Tumor Biology
Education and Positions:
Ph.D. Biochemistry, University of Minnesota
Highlight Detail
Acetylation and activation of STAT3 mediated by nuclear translocation of CD44.
Dr. Chen, Joanne Jeou-Yuan
J. Cell Biol, Jun 08, 2009Expression of the type I transmembrane glycoprotein CD44 has recently been recognized as a signature for cancer stem cells. In this study, we demonstrate that CD44, once engaged, is internalized and translocated to the nucleus, where it binds to various promoters.
Related Article (J. Cell Biol. 2009 185: 930.)
CD44's nuclear road trip.
EDITORS' CHOICE (Science Signaling)
STAT Signaling: No Phosphate, No Problem.