Dr. Jou, Yuh-Shan 周玉山 博士



  • PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility
    Cells, Jun 18, 2020
    Abstract Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associat ......
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  • Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma
    Nucleic Acids Research, Dec 19, 2019
    Precise noncoding RNA (ncRNA)-based network prediction is necessary to reveal ncRNA functions and pathological mechanisms. Here, we establis ......
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  • PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
    Nature Communications, Dec 16, 2019
    Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to metastasis. Paraspeckle component 1 (PSPC1) upregulation h ......
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  • A New Switch for TGFβ in Cancer
    Cancer Research, Jul 12, 2019
    The TGFβ cytokine plays dichotomous roles during tumor progression. In normal and premalignant cancer cells, the TGFβ signaling pa ......
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  • PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis
    Nature cell biology, Mar 28, 2018
    Activation of metastatic reprogramming is critical for tumour metastasis. However, more detailed knowledge of the underlying mechanism is ne ......
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List of Highlights