HIGHLIGHT
重要成果
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- Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines
- ACS Nano, Mar 16, 2023
- Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs) with symptoms ranging from ......
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- Accelerated clearance by antibodies against methoxy PEG depends on pegylation architecture
- Journal of Controlled Release, Jan 17, 2023
- Methoxy polyethylene glycol (mPEG) is attached to many proteins, peptides, nucleic acids and nanomedicines to ......
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- The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
- Communications Biology, Jan 11, 2022
- T cells are critically important for host defense against infections. T cell activation is specific because si ......
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- Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in mice
- Biomedicine & Pharmacotherapy, Dec 06, 2021
- Antibodies that bind polyethylene glycol (PEG) can be induced by pegylated biomolecules and also exist in a si ......
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- Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies
- ACS Nano, Sep 02, 2021
- Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, n ......
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- Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity
- Communications Biology, Mar 04, 2021
- Abstract Irinotecan inhibits cell proliferation and thus is used for the primary treatment of colorectal cancer. Metabolism of irinotec ......
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- Bispecific Antibody (HER2 × mPEG) Enhances Anti-Cancer Effects by Precise Targeting and Accumulation of mPEGylated Liposomes
- Acta Biomaterialia, May 15, 2020
- Abstract Targeted antibodies and methoxy-PEGylated nanocarriers have gradually become a mainstream of cancer therapy. To increase the a ......
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- Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex
- ACS Nano, Mar 06, 2020
- Anti-polyethylene glycol (PEG) antibodies are present in many healthy individuals as well as in patients receiving polyethylene glycol-funct ......
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- Both IgM and IgG Antibodies Against Polyethylene Glycol Can Alter the Biological Activity of Methoxy Polyethylene Glycol-Epoetin Beta in Mice
- Pharmaceutics, Dec 21, 2019
- Pre-existing antibodies that bind polyethylene glycol are present in about 40% of healthy individuals. It is currently unknown if pre-existi ......
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- Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer
- Biomaterials Science, Jun 28, 2019
- For those patients with HER2-overexpressing breast cancer, treatment with PEGylated liposomal doxorubicin (PLD) is inefficacious due to the ......
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