Dr. Shieh, Sheau-Yann
謝小燕 博士
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JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
Cell Death & Disease, Jul 18, 2022
Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the s ......
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Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation
Cell Death & Disease, Dec 11, 2020
Abstract B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and is a downstream target of p53 ......
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CHK2-mediated regulation of PARP1 in oxidative DNA damage response
Oncogene, Sep 25, 2018
Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation ......
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Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation
PNAS, May 07, 2018
Checkpoint kinase 1 (CHK1), a Ser/Thr protein kinase, is modified by the K63-linked ubiquitin chain in response to genotoxic stress, which p ......
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Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.
Nucl. Acids Res., Nov 03, 2015
Human Mps1 (hMps1) is a protein kinase essential for mitotic checkpoints and the DNA damage response. Here, we present new evidence that hMp ......
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List of Highlights
文件紀錄
JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
Cell Death & Disease Jul 18, 2022
Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation
Cell Death & Disease Dec 11, 2020
CHK2-mediated regulation of PARP1 in oxidative DNA damage response
Oncogene Sep 25, 2018
Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation
PNAS May 07, 2018
Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.
Nucl. Acids Res. Nov 03, 2015
Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.
J Biol Chem. Apr 24, 2014
Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1.
PNAS Mar 26, 2013
Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK–JMJD3–p16
INK4a
signaling axis.
Oncogene Oct 24, 2011
p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control.
Oncogene Mar 01, 2010
TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18.
Mol. Cell. Biol. Mar 30, 2009
Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.
Oncogene Mar 30, 2009
The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1.
Oncogene Jan 19, 2009
The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1
The EMBO Journal Aug 09, 2007
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