Dr. Shieh, Sheau-Yann 謝小燕 博士

List of Highlights
文件紀錄

• JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability

  Cell Death & Disease Jul 18, 2022

• Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation

  Cell Death & Disease Dec 11, 2020

• CHK2-mediated regulation of PARP1 in oxidative DNA damage response

  Oncogene Sep 25, 2018

• Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation

  PNAS May 07, 2018

• Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.

  Nucl. Acids Res. Nov 03, 2015

• Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.

  J Biol Chem. Apr 24, 2014

• Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1.

  PNAS Mar 26, 2013

• Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK–JMJD3–p16^INK4a signaling axis.

  Oncogene Oct 24, 2011

• p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control.

  Oncogene Mar 01, 2010

• TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18.

  Mol. Cell. Biol. Mar 30, 2009

• Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.

  Oncogene Mar 30, 2009

• The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1.

  Oncogene Jan 19, 2009

• The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1

  The EMBO Journal Aug 09, 2007