Dr. Wu, Cheng-Wen 吳成文 博士

EGFR Promotes Lung Tumorigenesis by Activating miR-7 through a Ras/ERK/Myc Pathway That Targets the Ets2 Transcriptional Repressor ERF.

Cancer Res., Nov 01, 2010

MicroRNAs (miRNA) mediate distinct gene regulatory pathways triggered by epidermal growth factor receptor (EGFR) activation, which occurs commonly in lung cancers with poor prognosis. In this study, we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic 「oncomiR」 and its role as a key mediator of EGFR signaling in lung cancer cells.

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