Dr. Wu, Cheng-Wen
Corresponding Research Fellow
Academician, Academia Sinica
- 02-26523016 (Lab) (Room No: 107)
- 02-26523075 (Fax)
-
Specialty:
- Gene Transcription
- Cancer Metastasis
- Gene & Stem Cell Therapy
Education and Positions:
Ph.D. Case Western Research Univ.
M.D. National Taiwan University
Highlight Detail
EGFR Promotes Lung Tumorigenesis by Activating miR-7 through a Ras/ERK/Myc Pathway That Targets the Ets2 Transcriptional Repressor ERF.
Dr. Wu, Cheng-Wen
Cancer Res., Nov 01, 2010MicroRNAs (miRNA) mediate distinct gene regulatory pathways triggered by epidermal growth factor receptor (EGFR) activation, which occurs commonly in lung cancers with poor prognosis. In this study, we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic 「oncomiR」 and its role as a key mediator of EGFR signaling in lung cancer cells.