Dr. Yang, Pan-Chyr ’s Lab楊泮池 博士 實驗室

TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma.

Trop-2, a cell surface glycoprotein, contains both extracellular epidermal growth factor-like and thyroglobulin type-1 repeat domains. Low TROP2 expression was observed in lung adenocarcinoma tissues as compared with their normal counterparts. The lack of expression could be due to either the loss of heterozygosity (LOH) or hypermethylation of the CpG island DNA of TROP2 upstream promoter region as confirmed by