Dr. Yang, Pan-Chyr
Joint Appointment Research Fellow
Academician, Academia Sinica
- 02-27899149 (Lab) (Room No: 511)
- 02-27858594 (Fax)
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Specialty:
- Cell and Molecular Biology
- Cancer genomics
Education and Positions:
M.D., Ph.D. National Taiwan University
Highlight Detail
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.
Dr. Yang, Pan-Chyr
Nat Commun., May 25, 2014Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity is maintained in vivo is unclear and is difficult to study in vitro. Here we establish a sustainable primary culture of Oct3/4(+)/Nanog(+) lung CSCs fed with CD90(+) cancer-associated fibroblasts (CAFs) to further advance our knowledge of preserving stem cells in the tumour microenvironment.