Dr. Yang, Pan-Chyr ’s Lab楊泮池 博士 實驗室


Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.

Nat Commun., May 25, 2014

Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity is maintained in vivo is unclear and is difficult to study in vitro. Here we establish a sustainable primary culture of Oct3/4(+)/Nanog(+) lung CSCs fed with CD90(+) cancer-associated fibroblasts (CAFs) to further advance our knowledge of preserving stem cells in the tumour microenvironment.

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