Dr. Shih, Chiaho 施嘉和 博士

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  • Hepatitis B virus virion secretion is a CRM1-spike-mediated late event
    Journal of Biomedical Science Jun 21, 2022
          Background: Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative tr ......
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  • CRM1-spike-mediated nuclear export of hepatitis B virus encapsidated viral RNA
    Cell Reports Mar 08, 2022
          Hepatitis B virus (HBV) is a global pathogen. We report here that the cellular CRM1 machinery can mediate nucl ......
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  • Persistence of Hepatitis B Virus DNA and the Tempos between Virion Secretion and Genome Maturation in a Mouse Model
    Journal of Virology Oct 29, 2019
    Hepatitis B virus (HBV) core protein (HBc) accumulates frequent mutations in natural infection. Wild-type HBV is known to secrete predominan ......
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  • Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model
    Journal of Biomedical Science Nov 11, 2019
    Background Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV- ......
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  • Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model
    Scientific Reports Jul 31, 2019
    Severe infection with the re-emerging enterovirus 71 (EV71 or EV-A71) can cause cardiopulmonary failure. However, in patients’ heart a ......
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