Dr. Shen, Chen-Yang
Distinguished Research Fellow
- 02-27899036 (Lab) (Room No: N143)
- 02-27823047 (Fax)
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Specialty:
- Molecular Epidemiology
- Cancer Genetics
- Personalized Medicine
Education and Positions:
Ph.D. Univ. of North Carolina at Chapel Hill
Highlight Detail
A novel estrogen receptor-microRNA 190a-PAR-1-pathway regulates breast cancer progression, a finding initially suggested by genome-wide analysis of loci associated with lymph-node metastasis.
Dr. Shen, Chen-Yang
Hum Mol Genet., Sep 22, 2013To identify microRNAs that are important in regulating breast cancer progression, the present study used data for the 199 961 single-nucleotide polymorphisms (SNPs) in 837 breast cancer patients genotyped in a recent genome-wide association study to identify loci associated with lymph node metastasis (LNM). SNPs tagging the 15q22.2 locus showed a significant association with LNM and miR-190a was found to be the only microRNA in this region.