Dr. Wu, Jer-Yuarn 's publons link picture

Dr. Wu, Jer-Yuarn

Research Fellow
  • 02-27899075 (Lab) (Room No: N520)
  • 02-27824066 (Fax)

Specialty:
  • Human Genetics
  • Pharmacogenetics
  • Genome Medicine

Education and Positions:
  • Ph.D, Duke University, USA


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Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

Dr. Wu, Jer-Yuarn
Nature Genetics, May 25, 2012

To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10−8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.