HIGHLIGHT
重要成果
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- Upregulation of PD-L1 by SARS-CoV-2 promotes immune evasion
- Journal of medical virology, Jan 07, 2023
- Patients with severe COVID-19 often suffer from lymphopenia, which is linked to T cell sequestration, cytokine ......
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- Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis
- American Journal of Cancer Research, Oct 15, 2022
- N-linked glycosylation of proteins is one of the post-translational modifications (PTMs) that shield tumor ant ......
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- Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro
- EBioMedicine, Nov 25, 2021
- Background: Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and ......
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- Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis
- American Journal of Cancer Research, Oct 15, 2021
- SARS-CoV-2 exploits the host cellular machinery for virus replication leading to the acute syndrome of coronavirus disease 2019 (COVID-19). ......
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- Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail
- American Journal of Cancer Research, May 15, 2021
- The engagement of human angiotensin-converting enzyme 2 (hACE2) and SARS-CoV-2 spike protein facilitate virus spread. Th ......
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- Targeting glycosylated PD-1 induces potent anti-tumor immunity
- Cancer Research, Mar 10, 2020
- Immunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) immune checkpoints represent a ......
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- MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1
- Gastroenterology, May 01, 2019
- In HCC, c-MET blockade drives PD-L1 expression and T cell inactivation in immune-competent mice. Thus, anti-PD-1 enhances the efficacy of c- ......
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- Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1
- Cancer Cell, Feb 12, 2019
- ◆ Salatino M, Girotti M, Rabinovich GA. Preview: “Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer” ◆ ......
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- Deubiquitination and Stabilization of PD-L1 by CSN5
- Cancer Cell, Dec 12, 2016
- ◆ Grinberg-Bleyer Y, Ghosh S. Preview: “A novel link between inflammation and cancer” Cancer Cell 30(6):829-830, 2017. ◆ Rese ......
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- Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
- Nature Communications, Aug 30, 2016
- ◆ Selected as 2016: Signaling Breakthroughs of the year by Sci Signaling In this study, we discovered that glycosylation and stabilizatio ......
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