HIGHLIGHT DETAIL
重要成果詳細內容
Deubiquitination and Stabilization of PD-L1 by CSN5
Cancer Cell, Dec 12, 2016◆ Grinberg-Bleyer Y, Ghosh S. Preview: “A novel link between inflammation and cancer” Cancer Cell 30(6):829-830, 2017.
◆ Research Watch--“Chronic inflammation promotes CSN5-mediated PD-L1 stabilization”. Cancer Discovery (DOI:10.1158/2159-8290. CD-RW2016-224) December 2, 2016.
◆ Selected as 2016: Signaling Breakthroughs of the year by Sci Signaling
In this study, we demonstrated an immunosuppressive mechanism of cancer cells through a , CSN5-mediated stabilization of PD-L1 via TNF-a pathways. Importantly, inhibition of TNF-a-mediated PD-L1 stabilization in cancer cells promotes the tumor-infiltrating cytotoxic T cell immune response. Our results indicated that targeting cancer cell PD-L1 stabilization through NF-kB/CSN5 inhibition represents a potential strategy to treat cancers that are associated with inflammatory diseases.
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