Dr. Yang, Kai-Chien 楊鎧鍵 博士

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  • The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications
    Journal of Biomedical Science, Sep 02, 2022
          Fibrosis-related disorders account for an enormous burden of disease-associated morbidity and mortality worldw ......
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  • Targeting mechanosensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo
    Science Advances, Jan 21, 2022
          Although atherosclerosis preferentially develops at arterial curvatures and bifurcations where disturbed flow ......
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  • Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling
    Gut , Dec 21, 2021
            Background and objectives:  Liver fibrosis (LF) occurs following chronic liver injuries. Cur ......
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  • Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGFβ signaling in kidney fibroblasts
    Journal of Clinical Investigation, Jan 19, 2021
    Abstract Renal fibrosis, a common pathological manifestation of virtually all types of chronic kidney diseases (CKD), often results in di ......
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  • Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
    Nature Communications, Aug 26, 2020
    Pulmonary fibrosis (PF) is a major public health problem with limited therapeutic options. There is a clear need to identify novel mediators ......
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