Dr. Liu, Fu-Tong 劉扶東 博士

List of Highlights
文件紀錄

• Cytosolic galectin-4 enchains bacteria, restricts their motility, and promotes inflammasome activation in intestinal epithelial cells

  PNAS Jan 23, 2023

• The role of galectins in immunity and infection

  Nature Reviews Immunology Jan 16, 2023

• Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans

  PNAS Jul 27, 2021

• Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells.

  Nat Commun Apr 09, 2021

• Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses

  Journal of Biomedical Science Mar 04, 2021

• Galectin-8 Is Upregulated in Keratinocytes by IL-17A and Promotes Proliferation by Regulating Mitosis in Psoriasis.

  J Invest Dermatol Mar 01, 2021

• FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development.

  J Invest Dermatol Mar 01, 2021

• Galectin‐7 downregulation in lesional keratinocytes contributes to enhanced IL‐17A signaling and skin pathology in psoriasis

  Journal of clinical investigation Jan 04, 2021

• Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas.

  Nature Communications Aug 27, 2020

• Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)

  Journal of Biomedical Science Jun 04, 2020

• Intracellular Galectin-9 Enhances Proximal TCR Signaling and Potentiates Autoimmune Diseases.

  J Immunol Mar 01, 2020

• Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells

  Journal of Biomedical Science Jan 15, 2020

• Candida albicans triggers NADPH oxidase-independent neutrophil extracellular traps through dectin-2.

  PLoS pathogens Nov 06, 2019

• Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability.

  J Invest Dermatol Oct 25, 2019

• Intracellular galectins control cellular responses commensurate with cell surface carbohydrate composition.

  Glycobiology Sep 25, 2019

• Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease.

  Nature Communications Aug 02, 2019

• Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner.

  Glycobiology Oct 05, 2018

• Cytosolic galectin-3 and -8 regulate antibacterial autophagy through differential recognition of host glycans on damaged phagosomes.

  Glycobiology Feb 23, 2018

• Galectin-9 is Critical for Mucosal Adaptive Immunity through the TH17–IgA Axis

  American journal of pathology Feb 16, 2018

• Galectin-3 enhances avian H5N1 influenza A virus–induced pulmonary inflammation by promoting NLRP3 inflammasome activation

  The American Journal of Pathology Jan 20, 2018

• Cell Intrinsic Galectin-3 Attenuates Neutrophil ROS-Dependent Killing of Candida by Modulating CR3 Downstream Syk Activation.

  Front. Immunol. Feb 03, 2017

• Nanoimaging granule dynamics and subcellular structures in activated mast cells using soft X-ray tomography.

  Scientific Reports Oct 17, 2016

• Galectin-12 enhances inflammation by promoting M1 polarization of macrophages and reduces insulin sensitivity in adipocytes.

  Glycobiology Aug 03, 2016

• Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while promoting lipogenesis.

  J Leukoc Biol. Jun 02, 2016

• Galectin-3 level and the severity of cardiac diastolic dysfunction using cellular and animal models and clinical indices

  Scientific Reports Nov 19, 2015

• Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling.

  Journal of Investigative Dermatology Sep 22, 2015

• Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukemia Cells

  ACS Nano Jul 01, 2015

• Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6

  Glycobiology Nov 01, 2014

• Galectin-3 modulates Th17 responses by regulating dendritic cell cytokines

  American Journal of Pathology Oct 01, 2013

• Inducible deletion of the Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice

  PNAS Apr 01, 2013

• Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation

  Journal of Allergy and Clinical Immunology Dec 01, 2012

• Galectin-3 Regulates Intracellular Trafficking of EGFR through Alix and Promotes Keratinocyte Migration.

  Journal of Investigative Dermatology Dec 01, 2012

• Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice

  PNAS Sep 12, 2011

• Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response

  Journal of Experimental Medicine Aug 01, 2010

• Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse

  PNAS Aug 01, 2009

• Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis

  American Journal of Pathology Mar 01, 2009

• Endogenous Galectin-3 Is Localized in Membrane Lipid Rafts and Regulates Migration of Dendritic Cells

  Journal of Investigative Dermatology Mar 01, 2009

• Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation.

  J Invest Dermatol May 08, 2008

• Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression.

  J Immunol Oct 15, 2006

• Galectins as modulators of tumor progression

  Nature Reviews Cancer Jan 01, 2005

• Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma.

  Am J Pathol. Dec 01, 2004

• Suppression of tumor growth by galectin-7 gene transfer

  Cancer Research Aug 15, 2004

• Galectin-12 Is Required for Adipogenic Signaling and Adipocyte Differentiation.

  J Biol Chem Jul 09, 2004

• Critical role of galectin-3 in phagocytosis by macrophages

  Journal of Clinical Investigation Aug 01, 2003