Dr. Kannagi, Reiji 神奈木玲兒 博士

Transcription factors c-Myc and CDX₂ mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial–mesenchymal transition

PNAS May 15, 2012

Sialyl Lewis x (sLe^x) and sialyl Lewis a (sLe^a)   glycans are expressed on highly metastatic colon cancer cells. They   promote extravasation of cancer cells and tumor angiogenesis                       via interacting with E-selectin on endothelial   cells. Recently, epithelial–mesenchymal transition (EMT) has been noted   as                       a critical phenotypic alteration in metastatic   cancer cells.

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