Dr. Yang, Pan-Chyr ’s Lab楊泮池 博士 實驗室

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p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug.

Nature Cell Biology, May 19, 2009

The tumour suppressor p53 is known to prevent cancer progression by inhibiting proliferation and inducing apoptosis of tumour cells. Slug, an invasion promoter, exerts its effects by repressing E-cadherin transcription. Here we show that wild-type p53 (wtp53) suppresses cancer invasion by inducing Slug degradation, whereas mutant p53 may stabilize Slug protein.

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