Although chemotherapy has been improved for leukemia, patients with MLL-rearranged (MLL-r) leukemia exhibit poor treatment response and prognosis. SCUBE1 plays a critical pathogenic function in MLL-r leukemia by acting as a FLT3 coreceptor in facilitating the interaction between FLT3 ligand and FLT3, augmenting downstream LYN-AKT activation for leukemic cell survival and proliferation. ...(Read More)
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene. During HD progression, the level of the Translin-associated protein X (TRAX, a scaffold protein that mediates miRNA degradation) was markedly enhanced in the brain of patients and mice with HD. Such TRAX upregulation is protective in HD, ...(Read More)
The Taiwan Precision Medicine Initiative (TPMI), a project that aims to develop optimal strategies for health management by studying the genetic and clinical profiles of 1 million participants, reached the major milestone of enrolling ...(More)
Wuhan wild-type strain-based vaccines became almost ineffective against new SARS-CoV-2 variants. Academia Sinica mRNA Alpha team constructed a hybrid mRNA vaccine containing mutations of Omicron and Delta variants. When used as a booster in mice previously immunized with wild-type vaccine, the hybrid vaccine induced high titers of broadly neutralizing antibodies against all tested variants,…(More)
The sinoatrial node (SAN) initiates all heartbeats within the heart. The diseases of SAN result in catastrophic consequences from bradycardia to cardiac arrest. The sinoatrial node (SAN) is characterized by the microenvironment of pacemaker cardiomyocytes (PCs) encased with fibroblasts. A complex interaction between PCs and their microenvironment (especially fibroblasts) critically determines SAN function.