A new technique that polymerizes cellular cytosol with hydrogel generates robust biomimetic antigen presenting systems for anticancer adoptive T cell therapy.
Adoptive T cell therapy that extracts, expands, and reinfuses endogenous T cells from patents’ body is an emerging therapeutic regimen that has demonstrated compelling therapeutic benefits against cancer and chronic viral infections. …more
Aptamer-modified nanoparticles hitchhikes circulating monocytes to achieve precise drug delivery to cardiac infarct site and tumor.
One of the major challenges in modern pharmacological treatment is the difficulty to precisely deliver the drugs to the sites for treatment. Dr. Hsieh’s team used a technology called Cell-Systematic Evolution of Ligands by Exponential Enrichment (Cell-SELEX) to select a monocyte-specific aptamer from the oligonucleotide library of more than a quadrillion (1015) sequences. The aptamer can be easily modified on the liposomes. The aptamer-liposomes are stable and can be loaded with various drugs of interests.
The extracellular microenvironment provides the biochemical signals that control cell behavior and coordinate developmental and physiological processes. Any imbalance of such delicate regulation can considerably affect development and homeostasis. A research team composed of Dr. Ruey-Bing Yang (Research Fellow of Academia Sinica) and Dr. Yuh-Charn Lin (Research Scholar) of the Institute of Biomedical Sciences identified …(Read More)
Lung cancer is the leading cause of cancer death in Taiwan and the world, and its treatment has always been a topic of concern in the country. A research team composed of Drs. Pan-Chyr Yang (Academician of Academia Sinica), Shu-Ping Wang (Assistant Research Fellow) and Chia-Sing Lu (Postdoctoral Fellow) of the Institute of Biomedical Sciences, found that the chemotherapeutic agent …(Read More)
Academia Sinica Vice President Dr. Fu-Tong Liu is a pioneer and leader in the field of galectin research. Not only was he the discoverer of now well-known galectin-3, he also found that different galectins play very important functions in different diseases, and different galectins have the potential to become targets for the treatment of different diseases. …(Read More)
As is well known, psychological stress can result in psychiatric disorders, such as depression and anxiety. But do you know that repeated exposure to psychological stress can also cause chronic physical pain? Dr. Chih-Cheng Chen, research fellow in the Institute of Biomedical Sciences, Academia Sinica …(Read More)