Wuhan wild-type strain-based vaccines became almost ineffective against new SARS-CoV-2 variants. Academia Sinica mRNA Alpha team constructed a hybrid mRNA vaccine containing mutations of Omicron and Delta variants. When used as a booster in mice previously immunized with wild-type vaccine, the hybrid vaccine induced high titers of broadly neutralizing antibodies against all tested variants,…(More)
The sinoatrial node (SAN) initiates all heartbeats within the heart. The diseases of SAN result in catastrophic consequences from bradycardia to cardiac arrest. The sinoatrial node (SAN) is characterized by the microenvironment of pacemaker cardiomyocytes (PCs) encased with fibroblasts. A complex interaction between PCs and their microenvironment (especially fibroblasts) critically determines SAN function.
Tissue-protective cytokine IL-22 targets epithelial lineages such as the gastrointestinal system. Clinical relevance of IL-22 to IBD is well-established and IL-22 therapy is promising for IBD treatment as IL-22 is capable of promoting epithelial repair and inducing production of anti-microbial peptides. The group identify a novel anti-bacterial circuit, showing during E coli infection, IL-22 initiates an IL-18 ...(More)
How does the immune system eradicate SARS-CoV-2-infected cells? Why does the viral clearance rate differ among patients? In a study published in Journal of Clinical Investigation, a team led by Dr. Shih-Yu Chen at the Institute of Biomedical Sciences, Academia Sinica, showed that natural killer (NK) cells are the key immune cells responsible for the rate of SARS-CoV-2 viral clearance. ...(More)