Registration Deadline: March 1st, 2020. Link
Cancer metastasis is responsible for majority of cancer patient death. However, how cancer cells turn on the molecular metastatic switch to spread the reprogrammed cancer cells to the distant organ to cause lethality remain elusive. Therefore, targeting prognosis-related metastasis driver genes with understanding of the pathological mechanisms is critical to eliminating the metastatic signaling and prolonging the life of cancer patients. Previous reports by Dr. Yuh-Shan Jou and his lab members at the Institute of Biomedical Sciences of Academia Sinica in Taiwan identified PSPC1 (paraspeckle component 1) upregulation as the master modulator and transforming growth factor b1 (TGF-b1) pro-metastatic switch to augment cancer epithelial to mesenchymal transition (EMT), stemness and metastasis (Nature Cell Biology, 2018 and Cancer Research, 2019).
This study is one of very few to examine the relationship between attention deficit hyperactivity disorder (ADHD) and allergies, in combination with indicators of inflammation and immune responses, and to explore the potential inter-relationships among diet, nutritional biochemistry, and ADHD.
ADHD appears to be becoming more prevalent in children and it can have substantial impacts on children and their families. The work of Dr Wen-Harn Pan and colleague at Academia Sinica, National Taiwan University, Chang-Kung Medical Center, and Chung Hua University of Medical Technology explored comorbidities, biomarkers, and dietary and nutritional biochemistry profiles associated with ADHD with the ultimate aim to understand its complex etiology and improve diagnosis, prevention and management.
Dr Pan and her colleagues recruited 216 children diagnosed with ADHD, and 216 children without ADHD but who were similar in terms of age, sex, height and weight from 31 schools in Taiwan. The participants were elementary students and a diagnosis of ADHD was confirmed by child psychologist.