This study is one of very few to examine the relationship between attention deficit hyperactivity disorder (ADHD) and allergies, in combination with indicators of inflammation and immune responses, and to explore the potential inter-relationships among diet, nutritional biochemistry, and ADHD.
ADHD appears to be becoming more prevalent in children and it can have substantial impacts on children and their families. The work of Dr Wen-Harn Pan and colleague at Academia Sinica, National Taiwan University, Chang-Kung Medical Center, and Chung Hua University of Medical Technology explored comorbidities, biomarkers, and dietary and nutritional biochemistry profiles associated with ADHD with the ultimate aim to understand its complex etiology and improve diagnosis, prevention and management.
Dr Pan and her colleagues recruited 216 children diagnosed with ADHD, and 216 children without ADHD but who were similar in terms of age, sex, height and weight from 31 schools in Taiwan. The participants were elementary students and a diagnosis of ADHD was confirmed by child psychologist.
An international consortium comprised of scientists from the University of Texas Medical Branch, National Taiwan University, and Academia Sinica has developed a novel nanoparticle vaccine mimicking the morphology of MERS-CoV against the infectious pathogen. The nanoparticle vaccine has proven to be safe and effective against a lethal challenge of MERS-CoV in a transgenic mouse model.
Asthma is a chronic inflammatory disease affecting both children and adults. Recent studies have implicated group 2 innate lymphoid cells (ILC2s) in asthma development and exacerbation, breaking preconceived notions that T cells are the primary contributors of asthma. Importantly, ILC2s are associated with fungal allergen-associated severe asthma and corticosteroid resistant asthma in both children and adults. As such, they serve as an important therapeutic target for asthma treatment. A team led by Dr. Ya-Jen Chang discovered that ILC2-induced airway hyperreactivity (AHR) and lung inflammation could be suppressed by TLR9 immunostimulatory CpG motifs. They also demonstrate the therapeutic utility of a microparticle-based approach to locally deliver TLR9 ligands to the lungs. This study was published in the Journal of Allergy and Clinical Immunology on March 23rd, 2019.
Based on the research activities, our principle investigators can be divided into 6 areas: Epidemiology & Genetics Division, Neuroscience Division, Cardiovascular Research Division, Infectious Disease & Immunology Division, Cancer Division, and Structural Biology Division.