施嘉和 博士

Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model

Journal of Biomedical Science, Nov 11, 2019

Background Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV- ......

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謝清河 博士

Human iPSC banking: barriers and opportunities

Journal of Biomedical Science, Oct 28, 2019

The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new op ......

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嚴仲陽 博士

Palmitoyl acyltransferase activity of ZDHHC13 regulates skin barrier development partly by controlling PADi3 and TGM1 protein stability

Journal of Investigative Dermatology, Oct 25, 2019

Deficiency of the palmitoyl-acyl transferase ZDHHC13 compromises skin barrier permeability and renders mice susceptible to environmental bac ......

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張雅貞 博士

Pulmonary IL‐33 orchestrates innate immune cells to mediate RSV‐evoked airway hyperreactivity and eosinophilia

Allergy, Oct 17, 2019

Background Respiratory syncytial virus (RSV) infection is epidemiologically linked to asthma. During RSV infection, IL‐33 is elevated a ......

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林小喬 博士

Free and Bound Therapeutic Lithium in Brain Signaling

Accounts of Chemical Research, Sep 26, 2019

Lithium, a first-line therapy for bipolar disorder, is effective in preventing suicide and new depressive/manic episodes. Yet, how this begu ......

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林文昌 博士

Overlapping protein-coding genes in human genome and their coincidental expression in tissues

Scientific Reports, Sep 16, 2019

The completion of human genome sequences and the advancement of next-generation sequencing technologies have engendered a clear understandin ......

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陳儀莊 博士

Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors

Translational Psychiatry, Aug 27, 2019

Sialic acids are typically added to the end of glycoconjugates by sialyltransferases. Among the six ST8 α-N-acetyl-neuraminide α ......

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謝清河 博士

Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction

Theranostics, Aug 21, 2019

Rationale: Long non-coding RNA (lncRNAs) has been identified as a pivotal novel regulators in cardiac development as well as cardiac pathoge ......

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李永凌 博士

Assessing Causality Between Childhood Adiposity and Early Puberty: A Bidirectional Mendelian Randomization and Longitudinal Study

Metabolism, Aug 15, 2019

Aims Obesity and early puberty have been reported to be mutually causative. We investigated the causal relationship between adiposity a ......

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潘文涵 博士

Is Hyperuricemia, an Early-Onset Metabolic Disorder, Causally Associated with Cardiovascular Disease Events in Han Chinese?

Journal of Clinical Medicine, Aug 12, 2019

Background: Serum uric acid (SUA) has gradually been recognized as a potential risk factor for cardiovascular disease (CVD). However, whethe ......

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