楊泮池 博士

Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression

Cell, Jul 09, 2020

Summary Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To ......

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李永凌 博士

CEACAM3 Decreases Asthma Exacerbations and Modulates Respiratory Syncytial Virus Latent Infection in Children

Thorax, Jun 30, 2020

Abstract Background: Respiratory syncytial virus (RSV) is associated with childhood asthma. Nevertheless, not all children exposed to ......

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李德章 博士

Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives

Eur J Med Chem, Jun 23, 2020

Abstract A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates an ......

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周玉山 博士

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

Cells, Jun 18, 2020

Abstract Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associat ......

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劉扶東 博士

Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)

Journal of Biomedical Science, Jun 04, 2020

On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of ......

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楊泮池 博士

Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer

Journal of Controlled Release, Jun 01, 2020

Lung cancer is the primary cause of cancer-related death worldwide. 85%–90% of cases are non-small cell lung cancer (NSCLC) which char ......

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林小喬 博士

How the Local Environment of Functional Sites Regulates Protein Function

Journal of the American Chemical Society, May 19, 2020

Abstract Proteins form complex biological machineries whose functions in the cell are highly regulated at both the cellular and mol ......

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羅傅倫 博士

Bispecific Antibody (HER2 × mPEG) Enhances Anti-Cancer Effects by Precise Targeting and Accumulation of mPEGylated Liposomes

Acta Biomaterialia, May 15, 2020

Abstract Targeted antibodies and methoxy-PEGylated nanocarriers have gradually become a mainstream of cancer therapy. To increase the a ......

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沈志陽 博士

Tumorigenic and Metastatic Role of CD44−/low/CD24−/low Cells in Luminal Breast Cancer

Cancers, May 14, 2020

Abstract Cells with high CD44 but low CD24 expression (CD44high/CD24-/low) and high aldehyde dehydrogenase activity (ALDHbr) are widely ......

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林宜玲 博士

Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice

PLOS Pathogens, May 11, 2020

Abstract Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregna ......

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