Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation
Arteriosclerosis, Thrombosis, and Vascular Biology, Nov 05, 2020
Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and signi ......
Towards a reference genome that captures global genetic diversity
Nature Communications, Oct 30, 2020
The current human reference genome is predominantly derived from a single individual and it does not adequately reflect human ......
CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2α Expression Independent of RIG-I Signaling
Cell Reports, Oct 20, 2020
Eukaryotic mRNAs are 5′ end capped with a 7-methylguanosine, which is important for processing and translation of mRNAs. ......
Galectin‐7 downregulation in lesional keratinocytes contributes to enhanced IL‐17A signaling and skin pathology in psoriasis
Journal of clinical investigation, Oct 15, 2020
Psoriasis is a chronic inflammatory skin disease characterized by inflammatory cell infiltration, as well as hyperproliferatio ......
Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset
Scientific Reports, Oct 01, 2020
With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene trans ......
Inhibition of bacterial adherence to biomaterials by coating antimicrobial peptides with anionic surfactant
Colloids and Surfaces B: Biointerfaces, Sep 22, 2020
Medical devices are widely used in modern medicine, but their utilities are often limited by the biofilm formation of bacteria ......
Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain
Annals of the Rheumatic Diseases, Sep 09, 2020
Objectives: Fibromyalgia is commonly considered a stress-related chronic pain disorder, and daily stressors are known tri ......
Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation
Molecular Therapy, Sep 05, 2020
The amyloid precursor protein (APP) intracellular domain (AICD) is implicated in the pathogenesis of Alzheimer’s disease (AD), but pos ......
Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank
Journal of Biomedical Science, Sep 04, 2020
The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell ......
FUT8 remodeling of EGFR regulates epidermal keratinocyte proliferation during psoriasis development
Journal of Investigative Dermatology, Sep 02, 2020
α-(1,6)-fucosyltransferase (FUT8) is implicated in the pathogenesis of several malignancies, but its role in psoriasis i ......