[Activity] 2015/11/24

Structure and dynamics of Klebsiella pneumoniae response regulator PmrA in complex with promoter DNA give a deep insight into the mechanism of transcription activation.

A joint research group led by Dr. Chinpan Chen, a Research Fellow at the Institute of Biomedical Sciences (IBMS), and Dr. Chwan-Deng Hsiao, a Research Fellow at the Institute of Molecular Biology (IMB), has recently revealed the dynamics and structure of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA by nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography. Their results provide a deep insight into the mechanism of PmrA-activated gene expressions that lead to antibiotics resistance, which was published in the prestigious journal of Nature Communications on November 13, 2015.   ...more


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