Dr. Lin, Yi-Ling
Distinct Antiviral Roles for Human 2',5'-Oligoadenylate Synthetase Family Members against Dengue Virus Infection
The Journal of Immunology, Nov 18, 2009
The 2`,5`-oligoadenylate synthetase (OAS) and its downstream effector RNase L play important roles in host defense against virus infectio ......
Dr. Yang, Pan-Chyr
A Four-Gene Signature from NCI-60 Cell Line for Survival Prediction in Non–Small Cell Lung Cancer.
Clinical Cancer Research, Nov 17, 2009
Metastasis is the main cause of mortality in non–small cell lung cancer (NSCLC) patients. Genes that can discriminate the invasion ......
Dr. Li, Ling-Hui
Chromosomal and genetic alterations in human hepatocellular adenomas associated with type Ιa glycogen storage disease.
Human Molecular Genetics, Sep 16, 2009
Hepatocellular adenoma (HCA) is a frequent long-term complication of type I glycogen storage disease (GSD I) and malignant transformation ......
Dr. Tarn, Woan-Yuh
A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay.
Nucl Acids Res., Sep 03, 2009
Importin-β family members, which shuttle between the nucleus and the cytoplasm, are essential for nucleocytoplasmic transport of mac ......
Dr. Yang, Ruey-Bing (Ray)
Receptor guanylyl cyclases in Inka cells targeted by eclosion hormone.
PNAS, Jul 28, 2009
A signature of eclosion hormone (EH) action in insect ecdysis is elevation of cGMP in Inka cells, leading to massive release of ecdysis t ......
Dr. Lee, Eminy H.Y.
A novel defense mechanism that is activated on amyloid-beta insult to mediate cell survival: role of SGK1-STAT1/STAT2 signaling.
Cell Death Differ., Jul 17, 2009
Amyloid-beta (Abeta) is known to induce apoptotic cell death and its underlying mechanism has been studied extensively, but the endogenou ......
Dr. Chen, Joanne Jeou-Yuan
Acetylation and activation of STAT3 mediated by nuclear translocation of CD44.
J. Cell Biol, Jun 08, 2009
Expression of the type I transmembrane glycoprotein CD44 has recently been recognized as a signature for cancer stem cells. In this study ......
Dr. Tang, Tang K.
CPAP is a cell-cycle regulated protein that controls centriole length.
Nat Cell Biol., Jun 07, 2009
Centriole duplication involves the growing of a procentriole (progeny centriole) next to the proximal end of each pre-existing centriole ......
Dr. Pan, Wen-Harn
Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPAγ locus in Han Chinese1,2,3
Am J Clin Nutr, Jun 02, 2009
A large number of potential obesity loci have been reported. At least 18 genes have been replicated in a minimum of 5 studies on obesity- ......
Dr. Lim, Carmay
Determinants of K+ vs Na+ Selectivity in Potassium Channels
J. Am. Chem. Soc., May 20, 2009
Ion channels, specialized pore-forming proteins, are an indispensable component of the nervous system and play a crucial role in regulati ......