Dr. Hsieh, Patrick Ching-Ho
Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair
Circulation, Oct 08, 2018
Background: The impact of gut microbiota on the regulation of host physiology has recently garnered considerable attention, particularly in ......
Dr. Lim, Carmay
The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair
Journal of the American Chemical Society (JACS), Oct 08, 2018
The DNA base excision repair (BER) glycosylase MUTYH prevents DNA mutations by catalyzing adenine (A) excision from inappropriately formed 8 ......
Dr. Yen, Jeffrey J.Y.
CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia
Oncogene, Sep 29, 2018
High-frequency relapse remains a clinical hurdle for complete remission of T-cell acute lymphoblastic leukemia (T-ALL) patients, with hetero ......
Dr. Shieh, Sheau-Yann
CHK2-mediated regulation of PARP1 in oxidative DNA damage response
Oncogene, Sep 25, 2018
Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation ......
Dr. Huang, Yi-Shuian
CPEB2‐dependent translation of long 3′‐UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue
EMBO J, Sep 03, 2018
Expression of mitochondrial proton transporter uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) is essential for mammalian thermoge ......
Dr. Shyue, Song-Kun
Deletion of caveolin‐1 attenuates LPS/GalN‐induced acute liver injury in mice
Journal of Cellular and Molecular Medicine, Aug 22, 2018
Acute hepatic injury caused by inflammatory liver disease is associated with high mortality. This study examined the role of caveolin‐1 (Cav ......
Dr. Chen, Chih-Cheng
Involvement of advillin in somatosensory neuron subtype-specific axon regeneration and neuropathic pain
PNAS, Aug 20, 2018
Advillin is a sensory neuron-specific actin-binding protein expressed at high levels in all types of somatosensory neurons in early developm ......
Dr. Shen, Chen-Yang
Increased Cellular Levels of MicroRNA-9 and MicroRNA-221 Correlate with Cancer Stemness and Predict Poor Outcome in Human Breast Cancer
Cellular Physiology and Biochemistry, Aug 15, 2018
Background /Aims: Recent studies of microRNA (miRNA) involvement in tumorigenesis have indicated the critical role of these non-coding small ......
Dr. Chau, Lee-Young
Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics
Scientific Reports, Jul 31, 2018
Vascular smooth muscle cell (VSMC) migration play a key role in the development of intimal hyperplasia and atherosclerosis. Galectin-1 (Gal- ......
Dr. Tao, Mi-Hua
Combination of radiation and interleukin 12 eradicates large orthotopic hepatocellular carcinoma through immunomodulation of tumor microenvironment
OncoImmunology, Jul 23, 2018
Immunotherapies have shown promising results in certain cancer patients. For hepatocellular carcinoma (HCC), the multiplicity of an immunoto ......