Dr. Hsieh, Patrick Ching-Ho

The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling

Theranostics, May 09, 2018

Rationale: Lapatinib (LAP) is a crucial alternative to trastuzumab upon the onset of drug resistance during treatment of metastatic human ep ......

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Dr. Shieh, Sheau-Yann

Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation

PNAS, May 07, 2018

Checkpoint kinase 1 (CHK1), a Ser/Thr protein kinase, is modified by the K63-linked ubiquitin chain in response to genotoxic stress, which p ......

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Dr. Chang, Ya-Jen

IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury

Experimental & Molecular Medicine, Apr 20, 2018

The monolayered intrarenal urothelium covers the renal papilla and ureteropelvic junction (UPJ). In response to increased renal pressure dur ......

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Dr. Shen, Chen-Yang

SUMOylation of XRCC1 activated by poly(ADP-ribosyl)ation regulates DNA repair

Human Molecular Genetics, Apr 16, 2018

XRCC1 is an essential scaffold protein for base excision repair (BER) and helps to maintain genomic stability. XRCC1 has been indicated as a ......

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Dr. Roffler, Steve R.

High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation

Frontiers in Immunology, Apr 09, 2018

How T cell receptors (TCRs) are triggered to start signaling is still not fully understood. It has been proposed that segregation of the lar ......

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Dr. Chern, Yijuang

Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

Molecular Neurobiology, Apr 04, 2018

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and synaptic dysfunction. Adenosine is ......

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Dr. Chen, Chinpan

Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis

Scientific Reports, Apr 03, 2018

yclophilin 1 (TvCyP1), a cyclophilin type peptidyl-prolyl isomerase present in the human parasite Trichomonas vaginalis, interacts with Myb1 ......

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Dr. Lim, Carmay

Competition between Li+ and Na+ in sodium transporters and receptors: Which Na+-Binding sites are “therapeutic” Li+ targets?

Chemical Science, Apr 02, 2018

Sodium (Na+) acts as an indispensable allosteric regulator of the activities of biologically important neurotransmitter transporters and G-p ......

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Dr. Jou, Yuh-Shan

PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis

Nature cell biology, Mar 28, 2018

Activation of metastatic reprogramming is critical for tumour metastasis. However, more detailed knowledge of the underlying mechanism is ne ......

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Dr. Tarn, Woan-Yuh

RBM4 modulates radial migration via alternative splicing of Dab1 during cortex development

Molecular and cellular biology, Mar 26, 2018

The RNA-binding motif 4 (RBM4) protein participates in cell differentiation via its role in regulating the expression of or tissue-specific ......

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