Dr. Lee, Yungling Leo

Early Pubertal Maturation and Risk of Childhood Asthma: A Mendelian Randomization and Longitudinal Study

Allergy, Aug 06, 2019

BACKGROUND: Studies on early puberty and incident asthma have reported inconsistent results and are mainly performed in females. In this ......

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Dr. Yang, Pan-Chyr

4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin

European Journal of Medicinal Chemistry, Aug 02, 2019

Developing new therapeutic strategies to overcome drug resistance of cancer cells is an ongoing endeavor. From among 2 million chemicals, we ......

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Dr. Chern, Yijuang

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Nature Communications, Aug 02, 2019

Huntington’s disease (HD) is a neurodegenerative disorder that manifests with movement dysfunction. The expression of mutant Huntingti ......

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Dr. Shih, Chiaho

Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model

Scientific Reports, Jul 31, 2019

Severe infection with the re-emerging enterovirus 71 (EV71 or EV-A71) can cause cardiopulmonary failure. However, in patients’ heart a ......

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Dr. Jou, Yuh-Shan

A New Switch for TGFβ in Cancer

Cancer Research, Jul 12, 2019

The TGFβ cytokine plays dichotomous roles during tumor progression. In normal and premalignant cancer cells, the TGFβ signaling pa ......

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Dr. Roffler, Steve R.

Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer

Biomaterials Science, Jun 28, 2019

For those patients with HER2-overexpressing breast cancer, treatment with PEGylated liposomal doxorubicin (PLD) is inefficacious due to the ......

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Dr. Tarn, Woan-Yuh

uORF-mediated translational control: recently elucidated mechanisms and implications in cancer

RNA Biology, Jun 24, 2019

Protein synthesis is tightly regulated, and its dysregulation can contribute to the pathology of various diseases, including cancer. Increas ......

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Dr. Cheng, Ching-Feng

Targeting Protein Tyrosine Phosphatase PTP-PEST for Therapeutic Intervention in Acute Myocardial Infarction

Cardiovascular Research, Jun 22, 2019

Aims The myocardial ischemia/reperfusion (I/R) injury is almost inevitable since reperfusion is the only established treatment for acut ......

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Dr. Lee, Yungling Leo

Sialyl Glycan Expression on T Cell Subsets in Asthma: a correlation with disease severity and blood parameters

Scientific Reports, Jun 20, 2019

Memory T helper (Th) and regulatory T (Treg) cells play key roles in asthma. Certain sialyl carbohydrate determinants for selectins profound ......

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Dr. Lee, Eminy H.Y.

Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer’s disease

Cell Death & Differentiation, May 24, 2019

Amyloid-β (Aβ) oligomers largely initiate the cascade underlying the pathology of Alzheimer’s disease (AD). Galectin-3 (Gal- ......

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