Dr. Lee, Yungling Leo
Early Pubertal Maturation and Risk of Childhood Asthma: A Mendelian
Randomization and Longitudinal Study
Allergy, Aug 06, 2019
Studies on early puberty and incident asthma have reported inconsistent results and are mainly performed in females. In this ......
Dr. Yang, Pan-Chyr
4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin
European Journal of Medicinal Chemistry, Aug 02, 2019
Developing new therapeutic strategies to overcome drug resistance of cancer cells is an ongoing endeavor. From among 2 million chemicals, we ......
Dr. Chern, Yijuang
Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease
Nature Communications, Aug 02, 2019
Huntington’s disease (HD) is a neurodegenerative disorder that manifests with movement dysfunction. The expression of mutant Huntingti ......
Dr. Shih, Chiaho
Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model
Scientific Reports, Jul 31, 2019
Severe infection with the re-emerging enterovirus 71 (EV71 or EV-A71) can cause cardiopulmonary failure. However, in patients’ heart a ......
Dr. Jou, Yuh-Shan
A New Switch for TGFβ in Cancer
Cancer Research, Jul 12, 2019
The TGFβ cytokine plays dichotomous roles during tumor progression. In normal and premalignant cancer cells, the TGFβ signaling pa ......
Dr. Roffler, Steve R.
Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer
Biomaterials Science, Jun 28, 2019
For those patients with HER2-overexpressing breast cancer, treatment with PEGylated liposomal doxorubicin (PLD) is inefficacious due to the ......
Dr. Tarn, Woan-Yuh
uORF-mediated translational control: recently elucidated mechanisms and implications in cancer
RNA Biology, Jun 24, 2019
Protein synthesis is tightly regulated, and its dysregulation can contribute to the pathology of various diseases, including cancer. Increas ......
Dr. Cheng, Ching-Feng
Targeting Protein Tyrosine Phosphatase PTP-PEST for Therapeutic Intervention in Acute Myocardial Infarction
Cardiovascular Research, Jun 22, 2019
The myocardial ischemia/reperfusion (I/R) injury is almost inevitable since reperfusion is the only established treatment for acut ......
Dr. Lee, Yungling Leo
Sialyl Glycan Expression on T Cell Subsets in Asthma: a correlation with disease severity and blood parameters
Scientific Reports, Jun 20, 2019
Memory T helper (Th) and regulatory T (Treg) cells play key roles in asthma. Certain sialyl carbohydrate determinants for selectins profound ......
Dr. Lee, Eminy H.Y.
Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer’s disease
Cell Death & Differentiation, May 24, 2019
Amyloid-β (Aβ) oligomers largely initiate the cascade underlying the pathology of Alzheimer’s disease (AD). Galectin-3 (Gal- ......