Dr. Lee, Eminy H.Y.

PIAS1 Ser‐503 phosphorylation‐mediated Elk‐1 SUMOylation promotes neuronal survival in APP/PS1 mice

British Journal of Pharmacology, Mar 08, 2019

Background and purpose PIAS1 is phosphorylated by IKKα at Ser‐90 in a PIAS1 E3 ligase activity‐dependent manner. Whether PIAS1 is ......

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Dr. Chern, Yijuang

Enhanced Na+‐K+‐2Cl‐ cotransporter 1 underlies motor dysfunction in huntington's disease

MOVEMENT DISORDERS, Mar 06, 2019

Background Altered γ‐aminobutyric acid signaling is believed to disrupt the excitation/inhibition balance in the striatum, which ......

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Dr. Hu, Che-Ming (Jack)

Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions

Nature Communications, Mar 05, 2019

Cell membranes are an intricate yet fragile interface that requires substrate support for stabilization. Upon cell death, disassembly of the ......

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Dr. Yang, Pan-Chyr

A Novel TNF-α-Targeting Aptamer for TNF-α-Mediated Acute Lung Injury and Acute Liver Failure

Theranostics, Feb 28, 2019

Rationale: The TNF-α pathway plays as a double-edged sword that simultaneously regulates cell apoptosis and proliferation. The dysregu ......

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Dr. Yang, Ruey-Bing (Ray)

Epidermal growth factor-like repeats of SCUBE1 derived from platelets are critical for thrombus formation

Cardiovascular Research, Feb 05, 2019

Aims SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1), expressed in endothelial cells (ECs) and platelets, exists in soluble ......

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Dr. Kannagi, Reiji

Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, Feb 01, 2019

Normal colonic epithelial cells express sialyl 6-sulfo Lewisx and disialyl Lewisa on their cell surface, which are ligands for the immunosup ......

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Dr. Wu, Jer-Yuarn

Genome-wide transcriptome analysis to further understand neutrophil activation and lncRNA transcript profiles in Kawasaki disease

Scientific Reports, Jan 23, 2019

Kawasaki disease (KD) is the most common cause of acquired cardiac disease in children in developed countries. However, little is known rega ......

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Dr. Hsieh, Patrick Ching-Ho

Primary cardiac manifestation of autosomal dominant polycystic kidney disease revealed by patient induced pluripotent stem cell-derived cardiomyocytes

EBioMedicine, Jan 11, 2019

BACKGROUND: Mutations in PKD1 or PKD2 gene lead to autosomal dominant polycystic kidney disease (ADPKD). The mechanism of ADPKD progressi ......

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Dr. Lee, Te-Chang

IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling

oncogene, Jan 09, 2019

IFIT1 and IFIT3 are abundant products of interferon-stimulating genes. While the importance of IFIT1 and IFIT3 in the prognosis of cancer ha ......

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Record 41 to 49, total of 49 records