Dr. Lee, Eminy H.Y.
PIAS1 Ser‐503 phosphorylation‐mediated Elk‐1 SUMOylation promotes neuronal survival in APP/PS1 mice
British Journal of Pharmacology, Mar 08, 2019
Background and purpose
PIAS1 is phosphorylated by IKKα at Ser‐90 in a PIAS1 E3 ligase activity‐dependent manner. Whether PIAS1 is ......
Dr. Chern, Yijuang
Enhanced Na+‐K+‐2Cl‐ cotransporter 1 underlies motor dysfunction in huntington's disease
MOVEMENT DISORDERS, Mar 06, 2019
Altered γ‐aminobutyric acid signaling is believed to disrupt the excitation/inhibition balance in the striatum, which ......
Dr. Hu, Che-Ming (Jack)
Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions
Nature Communications, Mar 05, 2019
Cell membranes are an intricate yet fragile interface that requires substrate support for stabilization. Upon cell death, disassembly of the ......
Dr. Yang, Pan-Chyr
A Novel TNF-α-Targeting Aptamer for TNF-α-Mediated Acute Lung Injury and Acute Liver Failure
Theranostics, Feb 28, 2019
Rationale: The TNF-α pathway plays as a double-edged sword that simultaneously regulates cell apoptosis and proliferation. The dysregu ......
Dr. Yang, Ruey-Bing (Ray)
Epidermal growth factor-like repeats of SCUBE1 derived from platelets are critical for thrombus formation
Cardiovascular Research, Feb 05, 2019
SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1), expressed in endothelial cells (ECs) and platelets, exists in soluble ......
Dr. Kannagi, Reiji
Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers
Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, Feb 01, 2019
Normal colonic epithelial cells express sialyl 6-sulfo Lewisx and disialyl Lewisa on their cell surface, which are ligands for the immunosup ......
Dr. Wu, Jer-Yuarn
Genome-wide transcriptome analysis to further understand neutrophil activation and lncRNA transcript profiles in Kawasaki disease
Scientific Reports, Jan 23, 2019
Kawasaki disease (KD) is the most common cause of acquired cardiac disease in children in developed countries. However, little is known rega ......
Dr. Hsieh, Patrick Ching-Ho
Primary cardiac manifestation of autosomal dominant polycystic kidney disease revealed by patient induced pluripotent stem cell-derived cardiomyocytes
EBioMedicine, Jan 11, 2019
Mutations in PKD1 or PKD2 gene lead to autosomal dominant polycystic kidney disease (ADPKD). The mechanism of ADPKD progressi ......
Dr. Lee, Te-Chang
IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling
oncogene, Jan 09, 2019
IFIT1 and IFIT3 are abundant products of interferon-stimulating genes. While the importance of IFIT1 and IFIT3 in the prognosis of cancer ha ......