Dr. Roffler, Steve R.

Both IgM and IgG Antibodies Against Polyethylene Glycol Can Alter the Biological Activity of Methoxy Polyethylene Glycol-Epoetin Beta in Mice

Pharmaceutics, Dec 21, 2019

Pre-existing antibodies that bind polyethylene glycol are present in about 40% of healthy individuals. It is currently unknown if pre-existi ......

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Dr. Jou, Yuh-Shan

Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma

Nucleic Acids Research, Dec 19, 2019

Precise noncoding RNA (ncRNA)-based network prediction is necessary to reveal ncRNA functions and pathological mechanisms. Here, we establis ......

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Dr. Jou, Yuh-Shan

PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

Nature Communications, Dec 16, 2019

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to metastasis. Paraspeckle component 1 (PSPC1) upregulation h ......

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Dr. Pan, Wen-Harn

The Mediterranean diet reduces the genetic risk of chromosome 9p21 for myocardial infarction in an Asian population community cohort

Scientific Reports, Dec 05, 2019

The interaction of genetic susceptibility and dietary habits in cardiovascular disease (CVD) remains undetermined. The purpose of this study ......

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Dr. Pan, Wen-Harn

Individualized home-based exercise and nutrition interventions improve frailty in older adults: a randomized controlled trial

International Journal of Behavioral Nutrition and Physical Activity, Dec 02, 2019

Background Frail older adults are predisposed to multiple comorbidities and adverse events. Recent interventional studies have shown that ......

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Dr. Shen, Chen-Yang

The Causal Relationship of Circulating Triglycerides and Glycated Hemoglobin: A Mendelian Randomization Study

Journal of Clinical Endocrinology & Metabolism, Nov 30, 2019

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Dr. Lim, Carmay

Why Cellular Di/Triphosphates Preferably Bind Mg2+ and Not Ca2+

Journal of Chemical Theory and Computation, Nov 27, 2019

Di/triphosphates perform a multitude of essential tasks, being important components of many vital organic cofactors such as adenosine/guanos ......

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Dr. Pan, Wen-Harn

The causal role of elevated uric acid and waist circumference on the risk of metabolic syndrome components

International Journal of Obesity, Nov 21, 2019

Background/objectives Hyperuricemia has been found to cluster with multiple components of metabolic syndrome (MetS). It is unclear whethe ......

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Dr. Shih, Chiaho

Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model

Journal of Biomedical Science, Nov 11, 2019

Background Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV- ......

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Dr. Shih, Chiaho

Persistence of Hepatitis B Virus DNA and the Tempos between Virion Secretion and Genome Maturation in a Mouse Model

Journal of Virology, Oct 29, 2019

Hepatitis B virus (HBV) core protein (HBc) accumulates frequent mutations in natural infection. Wild-type HBV is known to secrete predominan ......

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