Dr. Huang , Yi-Shuian

CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2α Expression Independent of RIG-I Signaling

Cell Reports Oct 20, 2020

Summary Eukaryotic mRNAs are 5′ end capped with a 7-methylguanosine, which is important for processing and translation of mRNAs. ......

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Dr. Chen , Chih-Cheng

Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain

Annals of the Rheumatic Diseases Sep 09, 2020

Abstract Objectives: Fibromyalgia is commonly considered a stress-related chronic pain disorder, and daily stressors are known tri ......

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Dr. Lee , Eminy H.Y.

Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation

Molecular Therapy Sep 05, 2020

The amyloid precursor protein (APP) intracellular domain (AICD) is implicated in the pathogenesis of Alzheimer’s disease (AD), but pos ......

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Dr. Huang , Yi-Shuian

CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis

Journal of Biomedical Science Apr 15, 2020

Background Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. Genetic ......

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Dr. Lee , Eminy H.Y.

Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome

Scientific Reports Jan 23, 2020

The methyl-CpG-binding protein 2 gene, MECP2, is an X chromosome-linked gene encoding the MeCP2 protein, and mutations of MECP2 cause Rett s ......

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