Dr. Shih , Chiaho

Nucleic Acid Chaperone Activity Associated with the ARD Domain of Human Hepatitis B Virus Core Protein.

J Virol. Dec 18, 2013

Hepatitis B virus (HBV) DNA replication occurs within the HBV icosahedral core particles. HBV core protein (HBc) contains an arginine-rich d ......

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Dr. Lin , Yi-Ling

Ubiquitin-Specific Protease 13 Regulates IFN Signaling by Stabilizing STAT1.

J Immunol. Aug 12, 2013

The IFN immune system comprises type I, II, and III IFNs, signals through the JAK-STAT pathway, and plays central roles in host defense agai ......

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Dr. Liao , Fang

Melanoma Differentiation–Associated Gene 5 Senses Hepatitis B Virus and Activates Innate Immune Signaling to Suppress Virus Replication.

J Immunol. Aug 07, 2013

Retinoic acid–inducible gene-I (RIG-I) and melanoma differentiation–associated gene 5 (MDA5) belong to the RIG-I–like rece ......

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Dr. Shih , Hsiu-Ming

HIC1 interacts with and modulates the activity of STAT3.

Cell Cycle. Jun 21, 2013

Abstract: HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene, expression of which is frequently suppressed in human cancers. Very ......

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Dr. Shih , Chiaho

Identification of a Novel Antimicrobial Peptide from Human Hepatitis B Virus Core Protein Arginine-Rich Domain (ARD).

PLOS Pathogens. Jun 13, 2013

The rise of multidrug-resistant (MDR) pathogens causes an increasing challenge to public health. Antimicrobial peptides are considered a pos ......

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Dr. Shih , Hsiu-Ming

Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.

EMBO J. Feb 08, 2013

While numerous small ubiquitin-like modifier (SUMO) conjugated substrates have been identified, very little is known about the cellular sign ......

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Dr. Lin , Yi-Ling

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation.

Nucleic Acids Res. Jan 25, 2013

Monocyte chemoattractant protein 1-induced protein 1 (MCPIP1), belonging to the MCPIP family with highly conserved CCCH-type zinc finger and ......

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