Dr. Shih , Hsiu-Ming
Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction
Scientific Reports Dec 12, 2017
The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the cons ......
Dr. Shih , Chiaho
Heparin at physiological concentration can enhance PEG-free in vitro infection with human hepatitis B virus
Scientific Reports Oct 31, 2017
Hepatitis B virus (HBV) is a blood-borne pathogen responsible for chronic hepatitis, cirrhosis, and liver cancer. The mechanism of HBV entry ......
Dr. Hu , Che-Ming (Jack)
Targeting and Enrichment of Viral Pathogen by Cell Membrane
Cloaked Magnetic Nanoparticles for Enhanced Detection
ACS Applied Materials & Interfaces Oct 31, 2017
Attachment to cellular surfaces is a major attribute among infectious pathogens for initiating disease pathogenesis. In viral infections, vi ......
Dr. Liao , Fang
CCR6 Deficiency Impairs IgA Production and Dysregulates Antimicrobial Peptide Production, Altering the Intestinal Flora
Frontiers in Immunology Jul 11, 2017
Intestinal immunity exists as a complex relationship among immune cells, epithelial cells, and microbiota. CCR6 and its ligand–CCL20 a ......
Dr. Yen , Jeffrey J.Y.
Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction
Scientific Reports Jul 04, 2017
JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full ......
Dr. Chen , Steve S.-L.
Hepatitis C virus subverts human choline kinase-α to bridge PI4KIIIα and NS5A and upregulates PI4KIIIα activation, thereby promoting the translocation of the ternary complex to the ER for viral replication
Journal of Virology May 31, 2017
In this study, we elucidated the mechanism by which human choline kinase-α (hCKα) interacts with nonstructural protein (NS)5A an ......
Dr. Lee , Yungling Leo
Rapid adiposity growth increases risks of new-onset asthma and airway inflammation in children
International Journal of Obesity Apr 04, 2017
We aim to (1) examine the influence of long-term adiposity status/short-term adiposity changes on asthma with high ......