Dr. Lin , Yi-Ling

Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis

Emerging Microbes & Infections Nov 21, 2018

The genus Flavivirus contains many important pathogens, including dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (J ......

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Dr. Shui , Jr-Wen

ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases

Frontiers in Immunology Nov 05, 2018

In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the ......

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Dr. Hu , Che-Ming (Jack)

725Colistin Nanoparticle Assembly by Coacervate Complexation with Polyanionic Peptides for Treating Drug-Resistant Gram-Negative Bacteria

Acta Biomaterialia Oct 11, 2018

Amidst the ever-rising threat of antibiotics resistance, colistin, a decade-old antibiotic with lingering toxicity concern, is increasingl ......

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Dr. Yen , Jeffrey J.Y.

CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia

Oncogene Sep 29, 2018

High-frequency relapse remains a clinical hurdle for complete remission of T-cell acute lymphoblastic leukemia (T-ALL) patients, with hetero ......

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Dr. Tao , Mi-Hua

Combination of radiation and interleukin 12 eradicates large orthotopic hepatocellular carcinoma through immunomodulation of tumor microenvironment

OncoImmunology Jul 23, 2018

Immunotherapies have shown promising results in certain cancer patients. For hepatocellular carcinoma (HCC), the multiplicity of an immunoto ......

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Dr. Lee , Yungling Leo

Causal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis

International Journal of Obesity Jul 19, 2018

Background/objectives Obesity and asthma are common chronic diseases and have been reported to be mutually causative. We investigated the ......

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Dr. Lin , Yi-Ling

Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein

PLoS pathogens Jul 17, 2018

CCCH-type zinc-finger antiviral protein (ZAP) is a host factor that restricts the infection of many viruses mainly through RNA degradation, ......

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Dr. Lee , Yungling Leo

Genetic Profiles of Transcriptomic Clusters of Childhood Asthma Determine Specific Severe Subtype

Clinical & Experimental Allergy May 14, 2018

BACKGROUND: Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epitheliu ......

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Dr. Chang , Ya-Jen

IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury

Experimental & Molecular Medicine Apr 20, 2018

The monolayered intrarenal urothelium covers the renal papilla and ureteropelvic junction (UPJ). In response to increased renal pressure dur ......

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Dr. Lee , Yungling Leo

Childhood Asthma Clusters Reveal Neutrophil-Predominant Phenotype with Distinct Gene Expression

Allergy Mar 25, 2018

Background: Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical ......

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