Dr. Lin , Yi-Ling Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis
Emerging Microbes & Infections Nov 21, 2018The genus Flavivirus contains many important pathogens, including dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (J ......
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Dr. Shui , Jr-Wen ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases
Frontiers in Immunology Nov 05, 2018In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the ......
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Dr. Hu , Che-Ming (Jack) 725Colistin Nanoparticle Assembly by Coacervate Complexation with Polyanionic Peptides for Treating Drug-Resistant Gram-Negative Bacteria
Acta Biomaterialia Oct 11, 2018Amidst the ever-rising threat of antibiotics resistance, colistin, a decade-old antibiotic with lingering toxicity concern, is increasingl ......
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Dr. Yen , Jeffrey J.Y. CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia
Oncogene Sep 29, 2018High-frequency relapse remains a clinical hurdle for complete remission of T-cell acute lymphoblastic leukemia (T-ALL) patients, with hetero ......
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Dr. Tao , Mi-Hua Combination of radiation and interleukin 12 eradicates large orthotopic hepatocellular carcinoma through immunomodulation of tumor microenvironment
OncoImmunology Jul 23, 2018Immunotherapies have shown promising results in certain cancer patients. For hepatocellular carcinoma (HCC), the multiplicity of an immunoto ......
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Dr. Lee , Yungling LeoCausal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis
International Journal of Obesity Jul 19, 2018Background/objectives Obesity and asthma are common chronic diseases and have been reported to be mutually causative. We investigated the ......
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Dr. Lin , Yi-Ling Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein
PLoS pathogens Jul 17, 2018CCCH-type zinc-finger antiviral protein (ZAP) is a host factor that restricts the infection of many viruses mainly through RNA degradation, ......
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Dr. Lee , Yungling LeoGenetic Profiles of Transcriptomic Clusters of Childhood Asthma Determine Specific Severe Subtype
Clinical & Experimental Allergy May 14, 2018BACKGROUND: Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epitheliu ......
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Dr. Chang , Ya-Jen IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury
Experimental & Molecular Medicine Apr 20, 2018The monolayered intrarenal urothelium covers the renal papilla and ureteropelvic junction (UPJ). In response to increased renal pressure dur ......
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Dr. Lee , Yungling LeoChildhood Asthma Clusters Reveal Neutrophil-Predominant Phenotype with Distinct Gene Expression
Allergy Mar 25, 2018Background: Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical ......
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