Dr. Chang , Ya-Jen

α-Lactosylceramide protects against iNKT-mediated murine airway hyperreactivity and liver injury through competitive inhibition of CD1d binding.

Frontiers in Chemistry Nov 28, 2019

Invariant natural killer T (iNKT) cells, which are activated by T cell receptor (TCR)-dependent recognition of lipid-based antigens presente ......

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Dr. Shih , Chiaho

Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model

Journal of Biomedical Science Nov 11, 2019

Background Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV- ......

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Dr. Shih , Chiaho

Persistence of Hepatitis B Virus DNA and the Tempos between Virion Secretion and Genome Maturation in a Mouse Model

Journal of Virology Oct 29, 2019

Hepatitis B virus (HBV) core protein (HBc) accumulates frequent mutations in natural infection. Wild-type HBV is known to secrete predominan ......

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Dr. Yen , Jeffrey J.Y.

Palmitoyl acyltransferase activity of ZDHHC13 regulates skin barrier development partly by controlling PADi3 and TGM1 protein stability

Journal of Investigative Dermatology Oct 25, 2019

Deficiency of the palmitoyl-acyl transferase ZDHHC13 compromises skin barrier permeability and renders mice susceptible to environmental bac ......

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Dr. Chang , Ya-Jen

TLR9-dependent interferon production prevents group 2 innate lymphoid cell-driven airway hyperreactivity

Journal of Allergy and Clinical Immunology Sep 01, 2019

Background: Group 2 innate lymphoid cells (ILC2s) are important mediators of allergic asthma. Bacterial components such as unmethylated CpG ......

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Dr. Lee , Yungling Leo

Assessing Causality Between Childhood Adiposity and Early Puberty: A Bidirectional Mendelian Randomization and Longitudinal Study

Metabolism Aug 15, 2019

Aims Obesity and early puberty have been reported to be mutually causative. We investigated the causal relationship between adiposity a ......

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Dr. Lee , Yungling Leo

Early Pubertal Maturation and Risk of Childhood Asthma: A Mendelian Randomization and Longitudinal Study

Allergy Aug 06, 2019

BACKGROUND: Studies on early puberty and incident asthma have reported inconsistent results and are mainly performed in females. In this ......

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Dr. Shih , Chiaho

Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model

Scientific Reports Jul 31, 2019

Severe infection with the re-emerging enterovirus 71 (EV71 or EV-A71) can cause cardiopulmonary failure. However, in patients’ heart a ......

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Dr. Lee , Yungling Leo

Sialyl Glycan Expression on T Cell Subsets in Asthma: a correlation with disease severity and blood parameters

Scientific Reports Jun 20, 2019

Memory T helper (Th) and regulatory T (Treg) cells play key roles in asthma. Certain sialyl carbohydrate determinants for selectins profound ......

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Dr. Hu , Che-Ming (Jack)

Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

Advanced Functional Materials Apr 12, 2019

The continued threat of emerging, highly lethal infectious pathogens such as Middle East respiratory syndrome coronavirus (MERS‐CoV) calls f ......

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