Dr. Chang , Ya-Jen

Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis

Theranostics Jan 01, 2021

  Rationale The major cause of heart failure is myocardium death consequent to detrimental cardiac remodeling and fibrosis follow ......

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Dr. Liu , Fu-Tong

Galectin‐7 downregulation in lesional keratinocytes contributes to enhanced IL‐17A signaling and skin pathology in psoriasis

Journal of clinical investigation Oct 15, 2020

Abstract Psoriasis is a chronic inflammatory skin disease characterized by inflammatory cell infiltration, as well as hyperproliferatio ......

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Dr. Liao , You-Di

Inhibition of bacterial adherence to biomaterials by coating antimicrobial peptides with anionic surfactant

Colloids and Surfaces B: Biointerfaces Sep 22, 2020

Abstract Medical devices are widely used in modern medicine, but their utilities are often limited by the biofilm formation of bacteria ......

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Dr. Lee , Yungling Leo

FUT8 remodeling of EGFR regulates epidermal keratinocyte proliferation during psoriasis development

Journal of Investigative Dermatology Sep 02, 2020

Abstract α-(1,6)-fucosyltransferase (FUT8) is implicated in the pathogenesis of several malignancies, but its role in psoriasis i ......

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Dr. Shui , Jr-Wen

Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas

Nature Communications Aug 27, 2020

Galectin-9 is a risk factor for inflammatory Crohn’s disease in the gut. Our research reveal glycosylation of lysosomal membrane prote ......

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Dr. Lee , Yungling Leo

CEACAM3 Decreases Asthma Exacerbations and Modulates Respiratory Syncytial Virus Latent Infection in Children

Thorax Jun 30, 2020

Abstract Background: Respiratory syncytial virus (RSV) is associated with childhood asthma. Nevertheless, not all children exposed to ......

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Dr. Liu , Fu-Tong

Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)

Journal of Biomedical Science Jun 04, 2020

On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of ......

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Dr. Lin , Yi-Ling

Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice

PLOS Pathogens May 11, 2020

Abstract Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregna ......

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Dr. Chang , Ya-Jen

Pulmonary IL‐33 orchestrates innate immune cells to mediate RSV‐evoked airway hyperreactivity and eosinophilia

Allergy Apr 21, 2020

  Background Respiratory syncytial virus (RSV) infection is epidemiologically linked to asthma. During RSV infection, IL‐33 is ......

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Dr. Hu , Che-Ming (Jack)

Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy

Nano Letters Mar 17, 2020

Many favorable anticancer treatments owe their success to the induction immunogenic cell death (ICD) in cancer cells, which results in the r ......

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