Chern, Yijuang - IBMS, Sinica

Memorial

Dr. Chern, Yijuang

Distinguished Research Fellow

Division Chef

副所長

中央研究院院士

+886227899028 (Lab) (Room No: N333)
+886226523913 (Office)
02-27829143 (Fax)
bmychern@ibms

Specialty:

Signal Transduction
Gene Regulation
Neurodegeneration Disease

Education and Positions:

Ph.D. Univ. of Massachusetts

We focus on two interrelated research projects: (1) functional characterization of the A2A adenosine receptor (A2AR) and (2) development of novel therapeutic treatment for degenerative diseases including Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD).

A2AR is a major target of caffeine, the most widely used psychoactive substance in the world. My laboratory started from the cloning of this receptor many years ago, and have extend our research interests into the regulation and signal transduction of A2AR under pathophysiological conditions, especially in neurodegenerative diseases. We have also set out to identify and delineate novel pathogeneses (e.g., Galectins-mediated neuroinflammation and abnormal GABAergic signaling) in diseased brains so that better treatments can be designed.

In addition, we developed a group of adenosine analogues targeting simultaneously at A2AR and an adenosine transporter (ENT1). These compounds can enter the brain to enhance the adenosine tone, and can be used to treat mouse models of at least five protein aggregation diseases (including HD, ALS, SCA3, SCA7, AD, and Niemann-Pick type C disease). Results of our findings have led to the application and approvals of patents on applying these compounds to the development of therapeutic treatments for neurodegenerative diseases.

Our Team

PROGRAM

Mar 30, 2021 〈研之有物〉COVID-19抗疫作戰的關鍵少數─中研院P3實驗室開箱
Nov 11, 2020 2020.11.11中研講堂

Begin ~ End

Yan Hua Lee, BSc, Yu-Shuen Tsai, Che-Chang Chang, Chun-Chen Ho, Hsiu-Ming Shih, Hui-Mei Chen, Hsing-Lin Lai, Chia-Wei Lee, Yi-Chung Lee, Yi-Chu Liao, Ueng-Cheng Yang, Tzu-Hao Cheng, Yijuang Chern, and Bing-Wen Soong, A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis MOVEMENT DISORDERS 10.1002/mds.28896, 1-12 (2021-12) [JCR] [WOS]
Liu Yu-Ju, Kuo Hung-Chih, Chern Yijuang A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS Neurobiology of Disease 160, 105531 (2021) [JCR] [WOS]
Wu Kuo-Chen, Lee Chih-Yu, Chern Yijuang, Lin Chun-Jung Amelioration of lipopolysaccharide-induced memory impairment in equilibrative nucleoside transporter-2 knockout mice is accompanied by the changes in glutamatergic pathways Brain, Behavior, and Immunity 96, 187-199 (2021) [JCR] [WOS]
Yu-Ju Liu, Yijuang Chern Contribution of energy dysfunction to impaired protein translation in neurodegenerative diseases. Frontiers in Cellular Neuroscience 15, 668500 (2021) [JCR] [WOS]
Chang Ching-Pang, Wu Kuo-Chen, Lin Chien-Yu, Chern Yijuang Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases Journal of Biomedical Science 28(1), 70-94 (2021) [JCR] [WOS]
Ching-Pang Chang; Ya-Gin Chang; Pei-Yun Chuang; Anh Thi Ngoc Nguyen; Kuo-Chen Wu; Fang-Yi Chou; Sin-Jhong Cheng; Hui-Mei Chen; Lee-Way Jin; Kevin Carvalho; Vincent Huin; Luc Buée; Yung-Feng Liao; Chun-Jung Lin; David Blum; Yijuang Chern Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy Acta Neuropathologica Communications 9, 112-129 (2021) [JCR] [WOS]
Jen Wei-Ping, Chen Hui-Mei, Lin Yow-Sien, Chern Yijuang, Lee Yi-Ching Twist1 Plays an Anti-apoptotic Role in Mutant Huntingtin Expression Striatal Progenitor Cells Molecular Neurobiology 57(3),1688-1703 (2020-04) [JCR] [WOS]

Record 11 to 20, total of 128 records