Epidemiology & Genetics
Neuroscience
Cardiovascular Research
Infectious Disease & Immunology
Cancer
Structural Biology
Research Highlights
Dr. Yang, Pan-Chyr Cancer Research, Feb 09, 2021
PINK1-mediated inhibition of EGFR dimerization and activation impedes EGFR-driven lung tumorig ......
EGFR is established as a driver of lung cancer, yet the regulatory machinery underlying its oncogenic activity is not fully understood. PINK1 kinase is a key player in mitochondrial quality control, although its role in lung cance ...... MORE
Dr. Yang, Kai-Chien Journal of Clinical Investigation, Jan 19, 2021
Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGFβ signaling in ki ......
Abstract Renal fibrosis, a common pathological manifestation of virtually all types of chronic kidney diseases (CKD), often results in diffuse kidney scarring and predisposes to end-stage renal disease. Currently, there is no effective t ...... MORE
Dr. Chang, Ya-Jen Theranostics, Jan 01, 2021
Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis
Rationale The major cause of heart failure is myocardium death consequent to detrimental cardiac remodeling and fibrosis following myocardial infarction. The cardiac protective cytokine interleukin (IL)-33, which signals by ST2 ...... MORE
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