Dr. Patrick C.H. Hsieh’s team at the Institute of Biomedical Sciences, Academia Sinica uncovered a pivotal gut-heart axis in post-myocardial infarction (MI) cardiac repair. Employing human clinical samples, nonhuman primate disease models, and mouse cardiac injury models, they revealed the significance of butyrate-producing bacteria, particularly in synthesizing β-hydroxybutyrate post-injury. This breakthrough offers precision medication targets for MI through gut microbiota adjustments. The study, titled "Gut Butyrate-Producers Confer Post-Infarction Cardiac Protection", published in Nature Communications on Nov 9th, involved collaborators from National Cheng Kung University, China Medical University Hospital, Far Eastern Memorial Hospital, and the University of Wisconsin-Madison (UW-Madison). Funding was provided by the National Science and Technology Council, Academia Sinica, National Health Research Institutes, and UW-Madison.
A schematic diagram illustrates the critical role of gut butyrate-producing bacteria in post-MI cardiac repair by generating butyrate and beta-hydroxybutyrate (3-OHB). (Graph was created with Biorender)
Dr. Patrick C.H. Hsieh, Distinguished Research Fellow at Institute of Biomedical Sciences, Academia Sinica
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