Cardiovascular & Metabolic Diseases

  • Elucidation of the structure/function of genes related to the normal physiology and pathophysiology of cardiovasuclar system
  • Investigation of cellular signaling and molecular mechanisms underlying the vaso-& cardioprotection and disease pathogenesis
  • Investigation of the in vivo gene functions using animal models of cardiovascular and metabolic diseases
  • Development of therapeutic approaches for cardiovascular diseases
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Hsieh, Patrick Ching-Ho
Distinguished Research Fellow
Division Chief
Specialty
  • Stem cells and regenerative medicine
  • Nanoscience and nanomedicine
  • Translational Research
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Kwok, Pui-Yan
Director
Distinguished Research Fellow
Academician, Academia Sinica
Specialty
  • Human genetics
  • Genomics
  • DNA sequence variation
  • Complex trait analysis,
  • Pharmacogenetics
  • Biotechnology
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Pan, Wen-Harn
Distinguished Research Fellow
Specialty
  • Cardiovascular and nutritional epidemiology
  • Omics and disease risk
  • Nutrition survey and intervention
  • Precision preventive medicine
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Wu, Jer-Yuarn
Research Fellow
Specialty
  • Human Genetics
  • Pharmacogenetics
  • Genome Medicine
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Yang, Ruey-Bing (Ray)
Deputy Director
Research Fellow
Specialty

Signal transduction

Receptor biology

Vascular biology

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Shyue, Song-Kun
Associate Research Fellow
Specialty
  • Caveolin-1
  • Protein Degradation
  • PGs & Cardiovascular Diseases
  • Adenovirus vector gene therapy
     
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Yan, Yu-Ting
Associate Research Fellow
Specialty
  • Molecular Genetics
  • Cardiovascular Development 
  • Myofibrillogenesis
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Chen, Hung-Hsin
Assistant Research Fellow
Specialty
  1. Human Genome
  2. Genetic Epidemiology
  3. RNA-sequencing
  4. Biobank analysis
  5. Longitudinal analysis
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Lai, Shih-Lei (Ben)
Assistant Research Fellow
Specialty
  • Cardiovascular development and regeneration
  • Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease
  • Developmental genetics in fish models for human diseases
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Chen, Chien-Hsiun
Research Scientist
Specialty
  • Genetic Statistics
  • Genetic Epidemiology
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Chen, Yen-Hui
Research Scientist
Specialty
  • Laboratory Animal Science
  • Mouse phenotyping
  • Cardiovascular disease
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Cheng, Ching-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Integrative Physiology
  • Molecular Cardiology
  • Metabolic syndrome
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Hu, Yu-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty

1. Cardiac arrhythmias

2. Electrophysiology

3. Biological pacemakers

4. Artificial intelligence

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Yang, Kai-Chien
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Organ fibrosis and stromal biology
  • Cardiac regeneration
  • Non-coding RNA biology
  • Ion channel regulation and electrophysiology
  • Cardiac oxidative stress and arrhythmias
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Chang, Yi-Cheng
Joint Appointment Assistant Research Fellow
Joint
Specialty
  • Diabetes and Obesity
  • Genetic epidemiology
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Chen, Chien-Chang
Research Fellow
Cross Div.
Specialty
  • Chronic Pain
  • Calcium Channel
  • Cardiovascular Disease
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Hu, Che-Ming (Jack)
Associate Research Fellow
Cross Div.
Specialty

Biomaterials and Nanotechnology for Drug and Vaccine Development

Cardiovascular & Metabolic Diseases
- Research Highlights -
...
Dr. Chang , Yi-Cheng
A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators
Nature Communications Sep 25, 2023

Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing en ...

...
Dr. Hu , Che-Ming (Jack)
Synthetic control of living cells by intracellular polymerization
Trends in Biotechnology Sep 22, 2023

An emerging cellular engineering method creates synthetic polymer matrices inside cells. By contrast with classical genetic, enzymatic, or r ...

...
Dr. Lai , Shih-Lei (Ben)
Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration
eLife Jul 27, 2023

      Zebrafish exhibit a robust ability to regenerate their hearts following injury, and the immune system plays a ...

...
Dr. Yang , Ruey-Bing (Ray)
The biology of SCUBE
Journal of Biomedical Science May 26, 2023

    The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] famil ...

...
Dr. Hu , Che-Ming (Jack)
Lymph Node Follicle-Targeting STING Agonist Nanoshells Enable Single-Shot M2e Vaccination for Broad and Durable Influenza Protection
Advanced Science Apr 24, 2023

      The highly conserved matrix protein 2 ectodomain (M2e) of influenza viruses presents a compelling vaccine anti ...

...
Dr. Pan , Wen-Harn
Efficacy of Dietary Intervention with Group Activities on Dietary Intakes, Frailty Status, and Working Memory: A Cluster-Randomized Controlled Trial in Community Strongholds
Nutrients Apr 19, 2023

      Geriatric community centers often offer nutrition lectures to older adults. In order to make learning more int ...

...
Dr. Cheng , Ching-Feng
Green tea epigallocatechin gallate inhibits preadipocyte growth via the microRNA-let-7a/HMGA2 signaling pathway
Molecular Nutrition & Food Research Feb 24, 2023

      Scope: This study investigated the effect of epigallocatechin gallate (EGCG) on white and beige preadipoc ...

...
Dr. Chang , Yi-Cheng
ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking
Journal of Biomedical Science Feb 19, 2023

      Background: Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genet ...

...
Dr. Wu , Jer-Yuarn
A Functional Polymorphism Downstream of Vitamin A Regulator Gene CYP26B1 Is Associated with Hand Osteoarthritis
International Journal of Molecular Sciences Feb 03, 2023

      While genetic analyses have revealed ~100 risk loci associated with osteoarthritis (OA), only eight have been ...

...
Dr. Hu , Che-Ming (Jack)
Engineering Cyborg Bacteria Through Intracellular Hydrogelation
Advanced Science Jan 11, 2023

      Natural and artificial cells are two common chassis in synthetic biology. Natural cells can perform complex ta ...

Highlights of all Divisions

Years