Cardiovascular & Metabolic Diseases

  • Elucidation of the structure/function of genes related to the normal physiology and pathophysiology of cardiovasuclar system
  • Investigation of cellular signaling and molecular mechanisms underlying the vaso-& cardioprotection and disease pathogenesis
  • Investigation of the in vivo gene functions using animal models of cardiovascular and metabolic diseases
  • Development of therapeutic approaches for cardiovascular diseases
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Hsieh, Patrick Ching-Ho
Distinguished Research Fellow
Division Chief
Specialty
1. Cardiac repair and regeneration
2. Microbiota and metabolism
3. Human induced pluripotent stem cells
4. Targeted delivery of nanomedicin
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Wu, Jer-Yuarn
Research Fellow
Specialty
  • Human Genetics
  • Pharmacogenetics
  • Genome Medicine
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Yang, Ruey-Bing (Ray)
Research Fellow
Specialty

Signal transduction

Receptor biology

Vascular biology

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Shyue, Song-Kun
Associate Research Fellow
Specialty
  • Caveolin-1
  • Protein Degradation
  • PGs & Cardiovascular Diseases
  • Adenovirus vector gene therapy
     
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Chen, Hung-Hsin
Assistant Research Fellow
Specialty
  1. Human Genome
  2. Genetic Epidemiology
  3. RNA-sequencing
  4. Biobank analysis
  5. Longitudinal analysis
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Lai, Shih-Lei (Ben)
Assistant Research Fellow
Specialty
  • Cardiovascular development and regeneration
  • Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease
  • Developmental genetics in fish models for human diseases
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Chen, Chien-Hsiun
Research Scientist
Specialty
  • Genetic Statistics
  • Genetic Epidemiology
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Chen, Yen-Hui
Research Scientist
Specialty
  • Laboratory Animal Science
  • Mouse phenotyping
  • Cardiovascular disease
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Chang, Yi-Cheng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Diabetes and Obesity
  • Genetic epidemiology
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Cheng, Ching-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Integrative Physiology
  • Molecular Cardiology
  • Metabolic syndrome
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Hu, Yu-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty

1. Cardiac arrhythmias

2. Electrophysiology

3. Biological pacemakers

4. Artificial intelligence

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Yang, Kai-Chien
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Organ fibrosis and stromal biology
  • Cardiac regeneration
  • Non-coding RNA biology
  • Ion channel regulation and electrophysiology
  • Cardiac oxidative stress and arrhythmias
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Chen, Chien-Chang
Research Fellow
Cross Div.
Specialty
  • Chronic Pain
  • Calcium Channel
  • Cardiovascular Disease
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Hu, Che-Ming (Jack)
Associate Research Fellow
Cross Div.
Specialty

Biomaterials and Nanotechnology for Drug and Vaccine Development

Cardiovascular & Metabolic Diseases
- Research Highlights -
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Dr. Yang , Kai-Chien
Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling
Gut Dec 21, 2021

        Background and objectives:  Liver fibrosis (LF) occurs following chronic liver injuries. Cur ...

...
Dr. Cheng , Ching-Feng
The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning
Biomedicine & Pharmacotherapy Nov 25, 2021

    In this study, we investigated whether the activating transcription factor 3 (ATF3) inducer ST32db, a synthetic compound ...

...
Dr. Hu , Yu-Feng
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats
Nature Biomedical Engineering Nov 22, 2021

  Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent mature cardiac cells via genetic manip ...

...
Dr. Chen , Chien-Chang
FAK regulates cardiomyocyte mitochondrial fission and function through Drp1
FEBS Journal Nov 05, 2021

    Loss of the mitochondrial fission enzyme dynamin-related protein 1 (Drp1) in cardiomyocytes results in energy shortage a ...

...
Dr. Shyue , Song-Kun
Atypical antipsychotics and CD36 pathway
Metabolism: clinical and experimental Aug 06, 2021

    Background Clinical reports indicate that schizophrenia patients taking atypical antipsychotic drugs suffer from me ...

...
Dr. Hsieh , Patrick Ching-Ho
Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation
Pharmaceutics Aug 03, 2021

Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site ...

...
Dr. Pan , Wen-Harn
Adequate protein intake in older adults in the context of frailty: cross-sectional results of the Nutrition and Health Survey in Taiwan 2014–2017
The American Journal of Clinical Nutrition Aug 02, 2021

    Background Emerging evidence suggests that a dietary protein intake higher than the current recommended dietary all ...

...
Dr. Hu , Che-Ming (Jack)
Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation
Advanced Materials Jun 07, 2021

    The growing enthusiasm for cancer immunotherapies and adoptive cell therapies has prompted increasing interest in biom ...

...
Dr. Hu , Yu-Feng
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis
Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166088. May 01, 2021

    Point mutation in alcohol dehydrogenase 2 (ALDH2), ALDH2*2 results in decreased catalytic enzyme activity and has been ...

...
Dr. Chang , Yi-Cheng
Identification of Novel Biomarkers for Pre-diabetic Diagnosis Using a Combinational Approach
Frontiers in Endocrinology Apr 28, 2021

Reliable protein markers for pre-diabetes in humans are not clinically available. In order to identify novel and reliable protein markers fo ...

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