Cardiovascular & Metabolic Diseases

  • Elucidation of the structure/function of genes related to the normal physiology and pathophysiology of cardiovasuclar system
  • Investigation of cellular signaling and molecular mechanisms underlying the vaso-& cardioprotection and disease pathogenesis
  • Investigation of the in vivo gene functions using animal models of cardiovascular and metabolic diseases
  • Development of therapeutic approaches for cardiovascular diseases
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Hsieh, Patrick Ching-Ho
Distinguished Research Fellow
Division Chief
Specialty
1. Cardiac repair and regeneration
2. Microbiota and metabolism
3. Human induced pluripotent stem cells
4. Targeted delivery of nanomedicin
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Wu, Jer-Yuarn
Research Fellow
Specialty
  • Human Genetics
  • Pharmacogenetics
  • Genome Medicine
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Yang, Ruey-Bing (Ray)
Research Fellow
Specialty

Signal transduction

Receptor biology

Vascular biology

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Shyue, Song-Kun
Associate Research Fellow
Specialty
  • Caveolin-1
  • Protein Degradation
  • PGs & Cardiovascular Diseases
  • Adenovirus vector gene therapy
     
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Chen, Hung-Hsin
Assistant Research Fellow
Specialty
  1. Human Genome
  2. Genetic Epidemiology
  3. RNA-sequencing
  4. Biobank analysis
  5. Longitudinal analysis
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Lai, Shih-Lei (Ben)
Assistant Research Fellow
Specialty
  • Cardiovascular development and regeneration
  • Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease
  • Developmental genetics in fish models for human diseases
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Chen, Chien-Hsiun
Research Scientist
Specialty
  • Genetic Statistics
  • Genetic Epidemiology
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Chen, Yen-Hui
Research Scientist
Specialty
  • Laboratory Animal Science
  • Mouse phenotyping
  • Cardiovascular disease
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Chang, Yi-Cheng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Diabetes and Obesity
  • Genetic epidemiology
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Cheng, Ching-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Integrative Physiology
  • Molecular Cardiology
  • Metabolic syndrome
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Hu, Yu-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty

1. Cardiac arrhythmias

2. Electrophysiology

3. Biological pacemakers

4. Artificial intelligence

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Yang, Kai-Chien
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Organ fibrosis and stromal biology
  • Cardiac regeneration
  • Non-coding RNA biology
  • Ion channel regulation and electrophysiology
  • Cardiac oxidative stress and arrhythmias
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Chen, Chien-Chang
Research Fellow
Cross Div.
Specialty
  • Chronic Pain
  • Calcium Channel
  • Cardiovascular Disease
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Hu, Che-Ming (Jack)
Associate Research Fellow
Cross Div.
Specialty

Biomaterials and Nanotechnology for Drug and Vaccine Development

Cardiovascular & Metabolic Diseases
- Research Highlights -
...
Dr. Hsieh , Patrick Ching-Ho
Reprogramming‐derived gene cocktail increases cardiomyocyte proliferation for heart regeneration
EMBO Molecular Medicine Dec 23, 2016

Although remnant cardiomyocytes (CMs) possess a certain degree of proliferative ability, efficiency is too low for cardiac regeneration afte ...

...
Dr. Hsieh , Patrick Ching-Ho
Reloadable multidrug capturing delivery system for targeted ischemic disease treatment
Science Translational Medicine Nov 16, 2016

Human clinical trials of protein therapy for ischemic diseases have shown disappointing outcomes so far, mainly because of the poor circulat ...

...
Dr. Yang , Ruey-Bing (Ray)
Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis
Arteriosclerosis, Thrombosis, and Vascular Biology Nov 10, 2016

Approach and Results—SCUBE2 lentiviral overexpression in human ECs increased and short hairpin RNA knockdown inhibited VEGF-induced ...

...
Dr. Chang , Yi-Cheng
No increased risk of hospitalization for heart failure for patients treated with dipeptidyl peptidase-4 inhibitors in Taiwan
International Journal of Cardiology Oct 01, 2016

Abstract Background Saxagliptin has been reported to be associated with an increased risk of hospitalization for heart failure (HF). T ...

...
Dr. Hsieh , Patrick Ching-Ho
Biomimicking Platelet–Monocyte Interactions as a Novel Targeting Strategy for Heart Healing
Advanced Healthcare Materials Sep 05, 2016

In patients who survive myocardial infarction, many go on to develop congestive heart failure (CHF). Despite ongoing efforts to develop new ...

...
Dr. Hu , Che-Ming (Jack)
Synthetic Virus-like Particles Prepared via Protein Corona Formation Enable Effective Vaccination in an Avian Model of Coronavirus Infection
Biomaterials Aug 15, 2016

The ongoing battle against current and rising viral infectious threats has prompted increasing effort in the development of vaccine technolo ...

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Dr. Pan , Wen-Harn
Blood Pressure, Carotid Flow Pulsatility, and the Risk of Stroke: A Community-Based Study.
Stroke Aug 04, 2016

Background and Purpose—High blood pressure is a major cause of cardiovascular events, and carotid flow pulsatility may be associated ...

...
Dr. Wu , Jer-Yuarn
Novel susceptibility gene for nonfamilial hypokalemic periodic paralysis.
Neurology Mar 02, 2016

Objective: To identify susceptibility genes to nonfamilial hypokalemic periodic paralysis (hypoKPP) consisting of thyrotoxic periodic para ...

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Dr. Hwang , Ming-Jing
Proteins with highly evolvable domain architectures are non-essential but highly retained.
Mol Biol Evol. Jan 14, 2016

The functions of proteins are usually determined by domains, and the sequential order in which domains are connected to make up a protein ch ...

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