Cardiovascular & Metabolic Diseases

  • Elucidation of the structure/function of genes related to the normal physiology and pathophysiology of cardiovasuclar system
  • Investigation of cellular signaling and molecular mechanisms underlying the vaso-& cardioprotection and disease pathogenesis
  • Investigation of the in vivo gene functions using animal models of cardiovascular and metabolic diseases
  • Development of therapeutic approaches for cardiovascular diseases
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Hsieh, Patrick Ching-Ho
Distinguished Research Fellow
Division Chief
Specialty
1. Cardiac repair and regeneration
2. Microbiota and metabolism
3. Human induced pluripotent stem cells
4. Targeted delivery of nanomedicin
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Wu, Jer-Yuarn
Research Fellow
Specialty
  • Human Genetics
  • Pharmacogenetics
  • Genome Medicine
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Yang, Ruey-Bing (Ray)
Research Fellow
Specialty

Signal transduction

Receptor biology

Vascular biology

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Shyue, Song-Kun
Associate Research Fellow
Specialty
  • Caveolin-1
  • Protein Degradation
  • PGs & Cardiovascular Diseases
  • Adenovirus vector gene therapy
     
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Chen, Hung-Hsin
Assistant Research Fellow
Specialty
  1. Human Genome
  2. Genetic Epidemiology
  3. RNA-sequencing
  4. Biobank analysis
  5. Longitudinal analysis
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Lai, Shih-Lei (Ben)
Assistant Research Fellow
Specialty
  • Cardiovascular development and regeneration
  • Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease
  • Developmental genetics in fish models for human diseases
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Chen, Chien-Hsiun
Research Scientist
Specialty
  • Genetic Statistics
  • Genetic Epidemiology
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Chen, Yen-Hui
Research Scientist
Specialty
  • Laboratory Animal Science
  • Mouse phenotyping
  • Cardiovascular disease
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Chang, Yi-Cheng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Diabetes and Obesity
  • Genetic epidemiology
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Cheng, Ching-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Integrative Physiology
  • Molecular Cardiology
  • Metabolic syndrome
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Hu, Yu-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty

1. Cardiac arrhythmias

2. Electrophysiology

3. Biological pacemakers

4. Artificial intelligence

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Yang, Kai-Chien
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Organ fibrosis and stromal biology
  • Cardiac regeneration
  • Non-coding RNA biology
  • Ion channel regulation and electrophysiology
  • Cardiac oxidative stress and arrhythmias
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Chen, Chien-Chang
Research Fellow
Cross Div.
Specialty
  • Chronic Pain
  • Calcium Channel
  • Cardiovascular Disease
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Hu, Che-Ming (Jack)
Associate Research Fellow
Cross Div.
Specialty

Biomaterials and Nanotechnology for Drug and Vaccine Development

Cardiovascular & Metabolic Diseases
- Research Highlights -
...
Dr. Wu , Jer-Yuarn
Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans
American Journal of Human Genetics Jan 11, 2018

Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis characterized by generalized hyperpigmentation mottl ...

...
Dr. Wu , Jer-Yuarn
A genome-wide association study links small-vessel ischemic stroke to autophagy
Scientific Reports Nov 09, 2017

Genome-wide association studies (GWAS) can serve as strong evidence in correlating biological pathways with human diseases. Although ischemi ...

...
Dr. Hu , Che-Ming (Jack)
Targeting and Enrichment of Viral Pathogen by Cell Membrane Cloaked Magnetic Nanoparticles for Enhanced Detection
ACS Applied Materials & Interfaces Oct 31, 2017

Attachment to cellular surfaces is a major attribute among infectious pathogens for initiating disease pathogenesis. In viral infections, vi ...

...
Dr. Hwang , Ming-Jing
A proteome view of structural, functional, and taxonomic characteristics of major protein domain clusters
Scientific Reports Oct 27, 2017

Proteome-scale bioinformatics research is increasingly conducted as the number of completely sequenced genomes increases, but analysis of pr ...

...
Dr. Hsieh , Patrick Ching-Ho
Subcellular Localization of Survivin Determines Its Function in Cardiomyocytes
Theranostics Oct 13, 2017

Rationale: Reducing cardiomyocyte death and enhancing their proliferation after myocardial infarction is perhaps the single largest challeng ...

...
Dr. Chen , Chien-Chang
Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus
Nature Communications Oct 10, 2017

Myocardial infarction is the leading cause of death worldwide. Restoration of blood flow rescues myocardium but also causes ischemia-reperfu ...

...
Dr. Yang , Ruey-Bing (Ray)
FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation
Breast Cancer Research Oct 05, 2017

Background Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fuco ...

...
Dr. Yang , Ruey-Bing (Ray)
Guanylyl cyclase‐G is an alarm pheromone receptor in mice
EMBO Journal Sep 28, 2017

Many animals respond to threats by releasing alarm pheromones (APs) that warn conspecifics. In mice, detection of the AP 2‐sec‐butyl‐4,5‐dih ...

...
Dr. Hsieh , Patrick Ching-Ho
Fenugreek Compound (N55) Lowers Plasma Glucose through the Enhancement of Response of Physiological Glucagon-like peptide-1
Scientific Reports Sep 25, 2017

Glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) analogues are approved for treating type 2 diabetes, but are known to activate GLP-1R sign ...

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Dr. Wu , Jer-Yuarn
A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol
Nature Communications Sep 12, 2017

Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. However, some health ...

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