Cardiovascular & Metabolic Diseases

  • Elucidation of the structure/function of genes related to the normal physiology and pathophysiology of cardiovasuclar system
  • Investigation of cellular signaling and molecular mechanisms underlying the vaso-& cardioprotection and disease pathogenesis
  • Investigation of the in vivo gene functions using animal models of cardiovascular and metabolic diseases
  • Development of therapeutic approaches for cardiovascular diseases
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Hsieh, Patrick Ching-Ho
Distinguished Research Fellow
Division Chief
Specialty
1. Cardiac repair and regeneration
2. Microbiota and metabolism
3. Human induced pluripotent stem cells
4. Targeted delivery of nanomedicin
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Wu, Jer-Yuarn
Research Fellow
Specialty
  • Human Genetics
  • Pharmacogenetics
  • Genome Medicine
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Yang, Ruey-Bing (Ray)
Research Fellow
Specialty

Signal transduction

Receptor biology

Vascular biology

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Shyue, Song-Kun
Associate Research Fellow
Specialty
  • Caveolin-1
  • Protein Degradation
  • PGs & Cardiovascular Diseases
  • Adenovirus vector gene therapy
     
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Chen, Hung-Hsin
Assistant Research Fellow
Specialty
  1. Human Genome
  2. Genetic Epidemiology
  3. RNA-sequencing
  4. Biobank analysis
  5. Longitudinal analysis
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Lai, Shih-Lei (Ben)
Assistant Research Fellow
Specialty
  • Cardiovascular development and regeneration
  • Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease
  • Developmental genetics in fish models for human diseases
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Chen, Chien-Hsiun
Research Scientist
Specialty
  • Genetic Statistics
  • Genetic Epidemiology
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Chen, Yen-Hui
Research Scientist
Specialty
  • Laboratory Animal Science
  • Mouse phenotyping
  • Cardiovascular disease
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Chang, Yi-Cheng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Diabetes and Obesity
  • Genetic epidemiology
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Cheng, Ching-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Integrative Physiology
  • Molecular Cardiology
  • Metabolic syndrome
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Hu, Yu-Feng
Joint Appointment Associate Research Fellow
Joint
Specialty

1. Cardiac arrhythmias

2. Electrophysiology

3. Biological pacemakers

4. Artificial intelligence

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Yang, Kai-Chien
Joint Appointment Associate Research Fellow
Joint
Specialty
  • Organ fibrosis and stromal biology
  • Cardiac regeneration
  • Non-coding RNA biology
  • Ion channel regulation and electrophysiology
  • Cardiac oxidative stress and arrhythmias
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Chen, Chien-Chang
Research Fellow
Cross Div.
Specialty
  • Chronic Pain
  • Calcium Channel
  • Cardiovascular Disease
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Hu, Che-Ming (Jack)
Associate Research Fellow
Cross Div.
Specialty

Biomaterials and Nanotechnology for Drug and Vaccine Development

Cardiovascular & Metabolic Diseases
- Research Highlights -
...
Dr. Pan , Wen-Harn
Dietary Characteristics of Elders with Frailty and with Mild Cognitive Impairment: Cross-Sectional Findings and Implications from the Nutrition and Health Survey in Taiwan 2014-2017
Nutrients Dec 07, 2022

      It is unclear whether low dietary intake accompanied with multiple nutrient deficiencies or specific nutrient ...

...
Dr. Hu , Che-Ming (Jack)
In Situ Hydrogelation of Cellular Monolayers Enables Conformal Biomembrane Functionalization for Xeno-Free Feeder Substrate Engineering
Advanced Healthcare Materials Dec 01, 2022

      The intricate biochemical functionalities of cellular membranes have inspired numerous strategies for deriving ...

...
Dr. Chang , Yi-Cheng
GSK3α phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells
Journal of Cell Biology Nov 29, 2022

Insulin-stimulated translocation of glucose transporter 4 (GLUT4) to plasma membrane of skeletal muscle is critical for postprandial glucose ...

...
Dr. Hsieh , Patrick Ching-Ho
Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration
Circulation Nov 24, 2022

        BACKGROUND: Cardiac regeneration after injury is limited by the low proliferative capacity of adu ...

...
Dr. Pan , Wen-Harn
Pharmacometabolomic study of drug response to antihypertensive medications for hypertension marker identification in Han Chinese individuals in Taiwan
Computational and Structural Biotechnology Journal Nov 17, 2022

      Various groups of antihypertensive drugs targeting different pathways have been developed; however, the pharma ...

...
Dr. Chang , Yi-Cheng
Prediabetes and risk of active tuberculosis: a cohort study from Northern Taiwan
International Journal of Epidemiology Nov 09, 2022

Background Diabetes mellitus (DM) is a well-established risk factor for active tuberculosis (TB) infection. Despite the worldwide rapid ...

...
Dr. Hsieh , Patrick Ching-Ho
Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice
Theranostics Oct 17, 2022

        Background: The gut microbiota plays a vital role in maintaining tissue homeostasis and regulat ...

...
Dr. Hsieh , Patrick Ching-Ho
Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine
Theranostics Oct 17, 2022

        Rationale: Gut microbiota plays a crucial role in cancer development and treatment. Studies sho ...

...
Dr. Chang , Yi-Cheng
A saturated map of common genetic variants associated with human height
Nature Oct 12, 2022

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, bu ...

...
Dr. Pan , Wen-Harn
Positive or U-Shaped Association of Elevated Hemoglobin Concentration Levels with Metabolic Syndrome and Metabolic Components: Findings from Taiwan Biobank and UK Biobank
Nutrients Sep 27, 2022

      Iron overnutrition has been implicated with a higher risk of developing metabolic and cardiovascular diseases, ...

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