Cancer

  • Mechanisms of cell cycle checkpoints, nuclear receptors, post-translational modifications, and stemness factors in controlling growth and differentiation of cancer cells
  • Molecular mechanisms of signaling circuitries involved in cancer formation, progression and metastasis
  • Biomarkers for cancer treatment and prognosis
  • Antibody therapies, new anticancer agents, and mechanisms of established anticancer drugs
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Roffler, Steve R.
Distinguished Research Fellow
Division Chief
Specialty
  1. Antibody Engineering
  2. Directed Molecular Evolution
  3. Prodrugs
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Jou, Yuh-Shan
Distinguished Research Fellow
Specialty
  • Cancer Genomics
  • Molecular Cancer Biology
  • Bioinformatics
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Shen, Chen-Yang
Distinguished Research Fellow
Specialty
  • Molecular Epidemiology
  • Cancer Genetics
  • Personalized Medicine
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Lin, Wen-chang
Research Fellow
Specialty
  • Bioinformatics and databases
  • Tumor Biology and cancer biomarkers
  • miRNA and protein-coding gene discovery
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Shieh, Sheau-Yann
Research Fellow
Specialty
  • Cancer Cell Biology
  • Cell Cycle Signaling
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Shih, Hsiu-Ming
Research Fellow
Specialty
  • Protein-protein Interaction & Modification
  • Cancer Cell Signaling
  • Transcriptional Control
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Chen, Shih-Yu
Assistant Research Fellow
Specialty
  • Single cell analysis
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Lee, Yu-Ru
Assistant Research Fellow
Specialty
  • Cancer Genetics
  • Cancer Signaling, Post-translational Modifications, Non-coding RNAs
  • Cancer Biology, Targeted/Immunotherapy
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Li, Chia-Wei
Assistant Research Fellow
Specialty
  • Cancer immunotherapy
  • Antibody discovery
  • Cancer metastasis
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Wang, Shu-Ping
Assistant Research Fellow
Specialty
  • Molecular oncology, Cancer epigenetics
  • Biochemically defined cell free system
  • CRISPR-based genetic/epigenetic editing
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Suzuki, Jun
Joint Appointment Research Fellow
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Li, Ling-Hui
Research Scientist
Specialty
  • Cancer Genomics
  • Human Molecular Genetics
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Li, Fu-An
Associate Research Scientist
Specialty

  • Mass spectrometry

  • Proteomics

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Yang, Pan-Chyr
Joint Appointment Research Fellow
Academician, Academia Sinica
Joint
Specialty
  • Cell and Molecular Biology
  • Cancer genomics
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Tang, Tang K.
Vice President, Academia Sinica
Distinguished Research Fellow
Academician, Academia Sinica
Cross Div.
Specialty
  • Centrosome and Cilia Biogenesis
  • Mitosis
  • Neural Stem Cell Division
Cancer
- Research Highlights -
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Dr. Roffler , Steve R.
Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs
Journal of Controlled Release Feb 28, 2024

Engineering human enzymes for therapeutic applications is attractive but introducing new amino acids may adversely affect enzyme stability a ...

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Dr. Suzuki , Jun
In vivo CRISPR screening directly targeting testicular cells
Cell Genomics Feb 27, 2024

CRISPR-Cas9 short guide RNA (sgRNA) library screening is a powerful approach to understand the molecular mechanisms of biological phenomena. ...

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Dr. Lee , Yu-Ru
UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
Molecular Cell Feb 19, 2024

UFMylation is an emerging ubiquitin-like post-translational modification that regulates various biological processes. Dysregulation of the U ...

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Dr. Chen , Shih-Yu
Immunometabolic features of natural killer cells are associated with infection outcomes in critical illness
Frontiers in Immunology Feb 15, 2024

Immunosuppression increases the risk of nosocomial infection in patients with chronic critical illness. This exploratory study aimed to dete ...

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Dr. Shen , Chen-Yang
miR-622 Increases miR-30a Expression through Inhibition of Hypoxia-Inducible Factor 1α to Improve Metastasis and Chemoresistance in Human Invasive Breast Cancer Cells
Cancers (Basel) Feb 03, 2024

Hypoxia-inducible factor 1α (HIF-1α) plays a pivotal role in the survival, metastasis, and response to treatment of solid tumors ...

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Dr. Li , Chia-Wei
Post-translational Modification of PD-1: Potential Pathways for Cancer Immunotherapy
Cancer Research Jan 17, 2024

Activation of effector T cells leads to upregulation of PD-1, which can inhibit T cell activity following engagement with its ligand PD-L1. ...

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