Cancer

  • Mechanisms of cell cycle checkpoints, nuclear receptors, post-translational modifications, and stemness factors in controlling growth and differentiation of cancer cells
  • Molecular mechanisms of signaling circuitries involved in cancer formation, progression and metastasis
  • Biomarkers for cancer treatment and prognosis
  • Antibody therapies, new anticancer agents, and mechanisms of established anticancer drugs
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Roffler, Steve R.
Distinguished Research Fellow
Division Chief
Specialty
  1. Antibody Engineering
  2. Directed Molecular Evolution
  3. Prodrugs
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Jou, Yuh-Shan
Distinguished Research Fellow
Specialty
  • Cancer Genomics
  • Molecular Cancer Biology
  • Bioinformatics
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Tarn, Woan-Yuh
Distinguished Research Fellow
Specialty

 

  1. mRNA splicing in neuron
  2. translational control in cancer
  3. long non-coding RNA
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Lin, Wen-chang
Research Fellow
Specialty
  • Bioinformatics and databases
  • Tumor Biology and cancer biomarkers
  • miRNA and protein-coding gene discovery
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Shieh, Sheau-Yann
Research Fellow
Specialty
  • Cancer Cell Biology
  • Cell Cycle Signaling
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Shih, Hsiu-Ming
Research Fellow
Specialty
  • Protein-protein Interaction & Modification
  • Cancer Cell Signaling
  • Transcriptional Control
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Chen, Shih-Yu
Associate Research Fellow
Specialty
  • Single cell analysis
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Lee, Yu-Ru
Assistant Research Fellow
Specialty
  • Cancer Genetics
  • Cancer Signaling, Post-translational Modifications, Non-coding RNAs
  • Cancer Biology, Targeted/Immunotherapy
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Li, Chia-Wei
Assistant Research Fellow
Specialty
  • Cancer immunotherapy
  • Antibody discovery
  • Cancer metastasis
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Wang, Shu-Ping
Assistant Research Fellow
Specialty
  • Molecular oncology, Cancer epigenetics
  • Biochemically defined cell free system
  • CRISPR-based genetic/epigenetic editing
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Suzuki, Jun
Joint Appointment Research Fellow
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Li, Ling-Hui
Research Scientist
Specialty
  • Cancer Genomics
  • Human Molecular Genetics
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Li, Fu-An
Associate Research Scientist
Specialty

  • Mass spectrometry

  • Proteomics

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Tang, Tang K.
Vice President, Academia Sinica
Distinguished Research Fellow
Academician, Academia Sinica
Cross Div.
Specialty
  • Centrosome and Cilia Biogenesis
  • Mitosis
  • Neural Stem Cell Division
Cancer
- Research Highlights -
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Dr. Yang , Pan-Chyr
The role of PM2.5 exposure in lung cancer: mechanisms, genetic factors, and clinical implications
EMBO Molecular Medicine Nov 22, 2024

Lung cancer is one of the most critical global health threats, as the second most common cancer and leading cause of cancer deaths globally. ...

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Dr. Tang , Tang K.
Centrosome Migration and Apical Membrane Formation in Polarized Epithelial Cells: Insights from the MDCK Cyst Model
eLife Oct 10, 2024

Polarization is crucial for the proper functioning of epithelial cells. Early polarization features include the trafficking and enrichment o ...

...
Dr. Suzuki , Jun
Phospholipid scrambling induced by an ion channel/metabolite transporter complex
Nature Communications Aug 31, 2024

Cells establish the asymmetrical distribution of phospholipids and alter their distribution by phospholipid scrambling (PLS) to adapt to env ...

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Dr. Roffler , Steve R.
Liposomes with Low Levels of Grafted Poly(ethylene glycol) Remain Susceptible to Destabilization by Anti-Poly(ethylene glycol) Antibodies
ACS Nano Aug 09, 2024

Binding of anti-PEG antibodies to poly(ethylene glycol) (PEG) on the surface of PEGylated liposomal doxorubicin (PLD) in vitro and ...

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Dr. Lin , Wen-chang
Housekeeping protein-coding genes interrogated with tissue and individual variations
Scientific Reports May 30, 2024

Housekeeping protein-coding genes are stably expressed genes in cells and tissues that are thought to be engaged in fundamental cellular bio ...

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Dr. Shieh , Sheau-Yann
A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis
Cell Death & Differentiation May 07, 2024

Obesity is endemic to many developed countries. Overweight or obesity is associated with an increased risk of developing cancer. Dysfunction ...

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Dr. Suzuki , Jun
Genome-Wide Screening Approaches for Biochemical Reactions Independent of Cell Growth
Annual Review of Genomics and Human Genetics May 01, 2024

Genome-wide screening is a potent approach for comprehensively understanding the molecular mechanisms of biological phenomena. However, desp ...

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Dr. Tarn , Woan-Yuh
DDX3 regulates cancer immune surveillance via 3' UTR-mediated cell-surface expression of PD-L1
Cell Reports Mar 13, 2024

Programmed death-1 (PD-1)/PD ligand-1 (PD-L1)-mediated immune escape contributes to cancer development and has been targeted as an anti-canc ...

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Dr. Roffler , Steve R.
Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs
Journal of Controlled Release Feb 28, 2024

Engineering human enzymes for therapeutic applications is attractive but introducing new amino acids may adversely affect enzyme stability a ...

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Dr. Suzuki , Jun
In vivo CRISPR screening directly targeting testicular cells
Cell Genomics Feb 27, 2024

CRISPR-Cas9 short guide RNA (sgRNA) library screening is a powerful approach to understand the molecular mechanisms of biological phenomena. ...

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