2024 Highlights

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Dr. Tarn , Woan-Yuh
RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar foliation
Communications Biology Dec 30, 2024

Brain-derived neurotrophic factor (BDNF) plays important roles in brain development and neural function. Constitutive knockout of the splici ...

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Dr. Fann , Cathy S.-J.
A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort
Communications biology Dec 04, 2024

The contributing genetic factors of vertigo remain poorly characterized, particularly in individuals of non-European ancestries. Here we sho ...

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Dr. Liu , Fu-Tong
Galectins and Host-Pathogen Interactions: The roles in viral infections
Seminars in Immunology Nov 23, 2024

Galectins, a family of carbohydrate-binding proteins, play crucial roles in the host-virus interaction landscape. This review explores the m ...

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Dr. Yang , Pan-Chyr
The role of PM2.5 exposure in lung cancer: mechanisms, genetic factors, and clinical implications
EMBO Molecular Medicine Nov 22, 2024

Lung cancer is one of the most critical global health threats, as the second most common cancer and leading cause of cancer deaths globally. ...

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Dr. Lin , Yi-Ling
Emergence and increased epidemic potential of dengue variants with the NS5V357E mutation after consecutive years of transmission
iScience Nov 15, 2024

Arboviruses can intensify epidemics by acquiring single nucleotide variants, leading to clade replacement and severe outbreaks. We investiga ...

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Dr. Lee , Kuo-Sheng
Emergence of a brainstem somatosensory tonotopic map for substrate vibration
Nature Neuroscience Nov 15, 2024

Perceiving substrate-borne vibrations is a fundamental component of tactile perception. How location (somatotopy) and frequency tuning (tono ...

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Dr. Chang , Ya-Jen
α-GalCer sp2-iminoglycolipid analogs as CD1d-dependent iNKT modulators: Evaluation of their immunotherapeutic potential in murine models of asthma and autoimmune hepatitis
European Journal of Medicinal Chemistry Nov 15, 2024

Invariant natural killer T (iNKT) cells are a subset of innate T cells displaying powerful immunomodulatory functions. Despite extensive pre ...

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Dr. Chen , Chien-Chang
Separate anterior paraventricular thalamus projections differentially regulate sensory and affective aspects of pain
Cell Reports Nov 04, 2024

The experience of pain is complex, involving both sensory and affective components, yet the underlying neural mechanisms remain elusive. Her ...

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Dr. Chern , Yijuang
The role of adiponectin-AMPK axis in TDP-43 mislocalization and disease severity in ALS
Neurobiology of Disease Oct 28, 2024

Hypermetabolism is a prominent characteristic of ALS patients. Aberrant activation of AMPK, an energy sensor regulated by adiponectin, is kn ...

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Dr. Hu , Che-Ming (Jack)
Combinatorial leaky probiotic for anticancer immunopotentiation and tumor eradication
Cell Reports Medicine Oct 22, 2024

Combination therapies present a compelling therapeutic regimen against the immunosuppressive and heterogeneous microenvironment of solid tum ...

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